Current status of liver diseases in Korea: liver cirrhosis.
Current status of liver diseases in Korea: liver cirrhosis.
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DOI：
10.3350/kjhep.2009.15.s6.s40
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发表时间：
2009-12-01
期刊：
影响因子：
--
通讯作者：
Jang, Jeong Won
中科院分区：
文献类型：
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作者：
Jang, Jeong Won
肝硬化代表了几乎所有慢性肝病的最终共同途径，并且其特征在于富含纤维状胶原的细胞外基质的积累。肝硬化患者有发生许多潜在并发症的风险。肝硬化患者最常见的并发症是腹水，最致命的是静脉曲张出血。其他中晚期并发症包括自发性细菌性腹膜炎、肝性脑病和肝肾综合征。在过去的几十年里，韩国肝病的死亡率和发病率持续下降，这可能是由于普遍接种疫苗和有效的抗病毒治疗的实施。此外，最近在肝硬化的病理生理学的理解和各种肝硬化并发症的管理方法的进展将有助于在这个国家的患者的结果稳步改善。这篇综述文章概述了最近的变化，病因和预后，以及在韩国的肝硬化管理的进展。
Liver cirrhosis represents the final common pathway of virtually all chronic liver diseases, and is characterized by an accumulation of extracellular matrix rich in fibrillar collagens. Patients with cirrhosis are at risk of developing many potential complications. The most common complication seen in patients with liver cirrhosis is ascites, and the most lethal one is bleeding varices. Other intermediate and late stage complications include spontaneous bacterial peritonitis, hepatic encephalopathy, and hepatorenal syndrome. The mortality and morbidity attributable to liver disease in Korea have decreased continuously over the past decades, probably due to the implementation of universal vaccination and potent antiviral therapies. In addition, recent advances in the understanding of the pathophysiology of cirrhosis and in various management approaches to cirrhosis complications will contribute to the steady improvement in patient outcomes in this country. This review article outlines recent changes in etiologies and prognosis, and the advances in management of cirrhosis in Korea.