Thymidine Kinase Activity in Burkitt Lymphoblastoid Somatic Cell Hybrids After Induction of the EB Virus 1
Thymidine Kinase Activity in Burkitt Lymphoblastoid Somatic Cell Hybrids After Induction of the EB Virus 1
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EB 病毒 1 诱导后 Burkitt 类淋巴细胞体细胞杂交体中的胸苷激酶活性
DOI：
10.3181/00379727-142-37176
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发表时间：
1973
影响因子：
--
通讯作者：
F. Rapp
中科院分区：
文献类型：
--
作者：
R. Glaser;T. Ogino;J. Zimmerman;F. Rapp
摘要 经 5-碘脱氧尿苷 (IUDR) 处理后，可以从体细胞杂交体中拯救 Epstein-Barr 病毒 (EBV)。 EBV 诱导后，杂交细胞中的脱氧胸苷激酶活性增加。病毒诱导后，脱氧胞苷脱氨酶的活性没有显着增加。证据表明 EBV 基因组可能参与了观察到的酶活性增加。
Summary Epstein-Barr virus (EBV) can be rescued from somatic cell hybrids after treatment with 5-iododeoxyuridine (IUDR). Deoxythymidine kinase activity increased in the hybrid cells after induction of EBV. Activity of deoxycytidine deaminase did not increase significantly following induction of the virus. The evidence suggests that the EBV genome may participate in the increased enzyme activity observed.