MORPHOLOGICAL-CHANGES IN THE COCHLEA OF THE MOUSE AFTER THE ONSET OF HEARING
MORPHOLOGICAL-CHANGES IN THE COCHLEA OF THE MOUSE AFTER THE ONSET OF HEARING
复制标题
DOI：
10.1016/0378-5955(81)90038-1
复制
发表时间：
1981-01-01
期刊：
影响因子：
2.8
通讯作者：
AULBACHKRAUS, K
中科院分区：
文献类型：
--
作者：
KRAUS, HJ;AULBACHKRAUS, K
用5、10、12、15日龄小鼠和成年小鼠耳蜗（M. musculus，NMRI株）进行了光镜和电镜观察。在每种情况下，检查Corti器官的相同部分（距离Helicotrema 2.8-3.3 mm）。这些结果与先前研究中获得的听觉阈值（同一品系小鼠）的发展相关。结果表明，Corti器官的形态发育绝不是在对声刺激的行为反应开始时完成的。在此事件之后，发生以下形态学变化。基底膜丝染色更强烈，鼓膜覆盖层厚度大大减少，几乎完全消失。柱细胞的纤维染色更强烈，数量明显增加，外柱细胞和内柱细胞之间的角度增加，从而使Corti隧道的横截面积扩大。网状膜和顶盖膜之间的钩状连接（边缘柱）消失。这些形态变化的耳蜗力学的后果进行了讨论，特别是在增加听力的灵敏度。
The cochleae of 5, 10, 12 and 15 day old mice and of adults (M. musculus, strain NMRI) were studied by light microscopy and EM. In each case the same part of the organ of Corti (2.8-3.3 mm from the helicotrema) was examined. The results were correlated with the development of auditory thresholds (in mice of the same strain) obtained in a previous study. It was demonstrated that morphological development of the organ of Corti is by no means complete at the onset of behavioral responses to acoustic stimuli. After this event the following morphological changes occur. The basilar membrane filaments stain more intensely and the tympanic cover layer is greatly reduced in thickness and almost completely disappears. The filaments of the pillar cells stain more intensely and apparently increase in number, and the angle between the outer and inner pillar cells increases so that the cross-sectional area of the tunnel of Corti expands. Hook-shaped connections (marginal pillars) between the reticular membrane and the tectorial membrane disappear. The consequences of these morphological changes for the cochlear mechanics are discussed, especially in respect to the increase of sensitivity of hearing.