Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia
Enriched environment and spatial learning enhance hippocampal neurogenesis and salvages ischemic penumbra after focal cerebral ischemia
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DOI：
10.1016/j.nbd.2005.10.015
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发表时间：
2006-04-01
影响因子：
6.1
通讯作者：
Liu, JL
中科院分区：
文献类型：
--
作者：
Matsumori, Y;Hong, SM;Liu, JL
丰富的环境（EE）已被证明可以增加成人大脑的神经发生。本研究的目的是确定 EE 和空间学习对缺血性中风后神经发生的影响。雄性成年SD大鼠接受假手术或远端大脑中动脉闭塞（MCAO）。与假手术相比，MCAO 诱导同侧和对侧 DG 的祖细胞增殖和神经母细胞生成短暂增加，随后持续抑制，低于基线水平。与标准环境中饲养的大鼠相比，在 EE 结合空间学习 8 周后，假手术大鼠和 MCAO 大鼠的 DG 中神经元分化和神经发生有所增加。与假手术相比，EE/学习还恢复了 MCAO 后 DG 中神经母细胞的总数。此外，EE/学习增强了缺血半暗带中 NeuN 阳性细胞的密度，尽管在该区域没有检测到新的神经元。 (c) 2005 Elsevier Inc. 保留所有权利。
Enriched environment (EE) has been shown to increase neurogenesis in the adult brain. The aim of this study is to determine the effect of EE and spatial learning on neurogenesis following ischemic stroke. Male adult SD rats were subjected to sham surgery or distal middle cerebral artery occlusion (MCAO). MCAO induced a transient increase followed by a sustained depression of progenitor cell proliferation and neuroblast production below baseline level in both ipsilateral and contralateral DG compared to sham. Increased neuronal differentiation and neurogenesis in the DG were observed in both sham and MCAO rats following 8 weeks in the EE combined with spatial learning, compared to rats housed in the standard environment. EE/Learning also restored the total number of neuroblasts in the DG after MCAO compared to sham. Furthermore, EE/learning enhanced the density of NeuN positive cells in the ischemic penumbra, though no new neurons were detected in this region. (c) 2005 Elsevier Inc. All rights reserved.