Differential regulation of release of acetylcholine in the striatum in mice following continuous exposure to selective D1 and D2 dopaminergic agonists.
Differential regulation of release of acetylcholine in the striatum in mice following continuous exposure to selective D1 and D2 dopaminergic agonists.
复制标题
持续暴露于选择性 D1 和 D2 多巴胺能激动剂后小鼠纹状体乙酰胆碱释放的差异调节。
DOI：
10.1016/0028-3908(93)90133-n
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发表时间：
1993
影响因子：
4.7
通讯作者：
Weiss,B
中科院分区：
文献类型：
--
作者：
Wang,HY;Zhou,LW;Friedman,E;Weiss,B
The effect of continuously infusing the selective D1and D2dopamine receptor agonists, SKF 38393 and quinpirole, on the release of [3H]acetylcholine from prelabeled striatal slices was investigated. These biochemical parameters were correlated with the behavioral effects of these agonists. Acute injections of SKF 38393 or quinpirole did not affect either K+-stimulated or spontaneous release of [3H]acetylcholine. Chronic exposure to quinpirole reduced the K+-evoked release of [3H]acetylcholine by 25.7%; long-term treatment with SKF 38393 did not alter the release of [3H]acetylcholine, induced by K+stimulation. Addedin vitro, SKF 38393 increased the release of [3H]acetylcholine, from striatal slices. The effect of the D1dopamine receptor agonist,, SKT 38393 was reduced after 7-days of infusion of SKF 38393 but was enhanced by 7-days of infusion of quinpirole. Activation of D2dopamine receptors with quinpirole or of muscarinic receptors with carbachol induced an inhibition of release of [3H]acetylcholine. Chronic treatment with quinpirole diminished the response to thein vitroaddition of quinpirole. The ability of carbachol to inhibit release of acetylcholine was not altered by continuous treatment with either SKF 38393 or quinpirole. Continuous infusion of SKF 38393 produced an initial grooming behavior; this behavior disappeared by 2 hr and remained absent during the 7 days of infusion of SKF 38393. Similarly, continuous administration of quinpirole produced stereotyped behavior, which peaked at 1 hr and disappeared by 4 hr and remained absent for the duration of the infusion. These findings demonstrate that continuous exposure to D1or D2agonists caused receptor-selective functional desensitization of D1or D2dopamine receptors. The results also indicate that the D1and D2dopamine receptor systems, involved in the regulation of release of acetylcholine, may be functionally interrelated.
