Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery
Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery
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DOI：
10.1245/aso.2006.05.052
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发表时间：
2006-06-01
影响因子：
3.7
通讯作者：
Ciardiello, Fortunato
中科院分区：
文献类型：
--
作者：
Galizia, Gennaro;Lieto, Eva;Ciardiello, Fortunato
背景资料：为了探讨表皮生长因子受体（EGFR）表达的作用，作为一个预后指标，预测癌症的行为和临床结果在结肠癌患者进行潜在的根治性surgery.Methods：EGFR测定使用市售的免疫组化试剂盒进行组织从149例结肠癌患者接受主要手术治疗，并在25个正常的结肠粘膜标本从非癌患者。单变量和多变量分析显示EGFR阳性与疾病复发和生存相关。此外，p27，p53，和血管内皮生长因子的表达进行了评估，免疫组化在104例EGFR肿瘤表达和临床outcome.Results：EGFR表达检测约三分之一的结肠癌患者（53 149; 35.6%）。在126例治愈性治疗的患者中，EGFR表达与疾病复发和较差的生存率在单变量和多变量分析中均相关。在预测复发和生存的多变量模型中，Dukes分期、p27和EGFR表达是唯一的独立协变量。特别是，在Dukes' A和B患者的5年生存概率为96%的EGFR阴性和高p27表达的情况下，为30.7%的EGFR阳性和低p27表达cases.Conclusions：EGFR表达是一个独立的预后指标的疾病复发和生存不良的结肠癌患者接受根治性手术。在分子靶向治疗等新的治疗选择的背景下，这些发现表明，抗EGFR药物可以在EGFR阳性结肠癌患者的辅助治疗中进行评估。
Background: To investigate the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for prediction of cancer behavior and clinical outcomes in colon cancer patients undergoing potentially curative surgery.Methods: EGFR determination using a commercially available immunohistochemistry kit was performed in tissues from 149 colon cancer patients receiving primary surgical treatment and in 25 normal colon mucosa specimens from noncancer patients. EGFR positivity was correlated in univariate and multivariate analyses with disease recurrence and survival. In addition, p27, p53, and vascular endothelial growth factor expression were assessed by immunohistochemistry in 104 patients and correlated with EGFR tumor expression and clinical outcome.Results: EGFR expression was detected in approximately one third of colon cancer patients (53 of 149; 35.6%). In 126 curatively treated patients, EGFR expression was correlated with disease recurrence and worse survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, Dukes' staging, p27, and EGFR expression were the only independent covariates. In particular, in Dukes' A and B patients the 5-year survival probability was 96% for EGFR-negative and high p27 expression cases and was 30.7% for EGFR-positive and low p27 expression cases.Conclusions: EGFR expression was an independent prognostic indicator of disease recurrence and poor survival in colon cancer patients undergoing curative surgery. In the context of novel therapeutic options such as molecularly targeted therapies, these findings suggest that anti-EGFR drugs could be evaluated in the adjuvant treatment of EGFR-positive colon cancer patients.