New RuII Scaffold for Photoinduced Ligand Release with Red Light in the Photodynamic Therapy (PDT) Window
New RuII Scaffold for Photoinduced Ligand Release with Red Light in the Photodynamic Therapy (PDT) Window
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DOI：
10.1002/chem.201802405
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发表时间：
2018-08-09
影响因子：
4.3
通讯作者：
Turro, Claudia
中科院分区：
文献类型：
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作者：
Loftus, Lauren M.;Al-Afyouni, Kathlyn F.;Turro, Claudia
合成了四种新的 Ru-II 配合物 [Ru(tpy)(L)(CH3CN](+)，其中 tpy=2,2':6',2"-三联吡啶，L 代表一系列乙酰丙酮基配体，用于增强红光光诱导配体释放，lambda(irr) = 655 nm。这些配合物的金属到配体电荷转移 (MLCT)-M-1 跃迁发生红移尽管不存在额外的空间畸变，但配体解离的量子产率仍比 [Ru(tpy)(bpy)(CH3CN)](2+) (bpy = 2,2'-联吡啶) 高 5 至 7 倍，这一系列复合物代表了药物光笼的新支架，也是 Ru-II 光笼的首批例子之一，它可以在最佳光动力治疗 (PDT) 窗口中用光释放腈。组织渗透。
Four new Ru-II complexes, [Ru(tpy)(L)(CH3CN](+), where tpy=2,2':6',2"-terpyridine and L represents a series of acetylacetonate-based ligands, were synthesized for enhanced photoinduced ligand release with red light, lambda(irr) = 655 nm. The metal-to-ligand charge transfer, (MLCT)-M-1, transitions of these complexes are red-shifted and exhibit quantum yields of ligand dissociation that are five- to seven-fold greater than that of [Ru(tpy)(bpy)(CH3CN)](2+) (bpy = 2,2'-bipyridine), despite the absence of additional steric distortion. This series of complexes represents a new scaffold for drug photocaging and one of the first examples of Ru-II photocages that can release nitriles with light in the photodynamic therapy (PDT) window required for optimal tissue penetration.