Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease
Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease
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DOI：
10.1016/j.neuroimage.2011.01.017
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发表时间：
2011-04-15
期刊：
影响因子：
5.7
通讯作者：
Hilker, Ruediger
中科院分区：
文献类型：
--
作者：
Baudrexel, Simon;Witte, Torsten;Hilker, Ruediger
帕金森病（PD）与基底节-丘脑-皮质环的异常超同步性有关。丘脑底核（subthalamic nucleus，简称丘脑底核）高频刺激的临床效果表明，丘脑底核在帕金森病中受影响的运动网络中起着至关重要的作用。在这里，我们调查的功能连接（FC）配置文件的功能磁共振成像（fMRI）的静息状态BOLD相关性的基础上，逐体素。我们将停药状态下的早期PD患者（n = 31）与健康对照组（n = 44）进行了比较。分析显示，增加FC之间的帕金森病患者的大脑皮层和皮质运动区（BA 4和6），根据电生理研究。而且。初级运动皮层（M1）手部区域的FC分析显示，FC增加主要发现在基底神经节内的小脑区域。这些发现与最近的实验数据吻合良好，表明通过所谓的超直接运动皮层-丘脑底通路介导的STN-运动皮层同步性增加可能在PD的病理生理学中起着重要作用。根据患者是否存在震颤（n = 16）进行额外的亚组分析。与健康对照组相比，震颤患者的M1和初级感觉皮层的手部区域特异性地表现出增加的M1和初级感觉皮层。在非震颤患者中，还发现包括SMA在内的正中和中线皮质运动区之间的FC值增加。总之，我们的研究结果强调的重要性，作为一个关键节点的调制BG皮质运动网络活动的PD患者的大脑皮层。(C)2011 Elsevier Inc. All rights reserved.
Parkinson's disease (PD) is associated with abnormal hypersynchronicity in basal ganglia-thalamo-cortical loops. The clinical effectiveness of subthalamic nucleus (STN) high frequency stimulation indicates a crucial role of this nucleus within the affected motor networks in PD. Here we investigate alterations in the functional connectivity (FC) profile of the STN using resting state BOLD correlations on a voxel-by-voxel basis in functional magnetic resonance imaging (fMRI). We compared early stage PD patients (n = 31) during the medication-off state with healthy controls (n = 44). The analysis revealed increased FC between the STN and cortical motor areas (BA 4 and 6) in PD patients in accordance with electrophysiological studies. Moreover. FC analysis of the primary motor cortex (M1) hand area revealed that the FC increase was primarily found in the STN area within the basal ganglia. These findings are in good agreement with recent experimental data, suggesting that an increased STN-motor cortex synchronicity mediated via the so called hyperdirect motor cortex-subthalamic pathway might play a fundamental role in the pathophysiology of PD. An additional subgroup analysis was performed according to the presence (n = 16) or absence (n = 15) of tremor in patients. Compared to healthy controls tremor patients showed increased STN FC specifically in the hand area of M1 and the primary sensory cortex. In non-tremor patients, increased FC values were also found between the STN and midline cortical motor areas including the SMA. Taken together our results underline the importance of the STN as a key node for the modulation of BG-cortical motor network activity in PD patients. (C) 2011 Elsevier Inc. All rights reserved.