Biological plaque control: novel therapeutic approach to periodontal disease.
Biological plaque control: novel therapeutic approach to periodontal disease.
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DOI：
10.2334/josnusd.54.1
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发表时间：
2012-03
影响因子：
1.9
通讯作者：
N. Sugano
中科院分区：
文献类型：
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作者：
N. Sugano
尽管机械牙菌斑控制在控制牙周病方面发挥着重要作用，但大多数人并未正确实施机械牙菌斑控制。因此，使用洗必泰和抗生素的辅助化学斑块控制也被建议作为增强机械斑块控制的额外治疗策略。然而，辅助抗生素治疗的附加作用很小，而且局部洗必太治疗也并非没有副作用。鉴于目前的限制，需要新的生物膜控制方法。本综述讨论的新治疗方法分为两类：益生菌和疫苗。益生菌是牙周病学研究的一个有趣的新领域，旨在通过消除致病菌来实现生物菌斑控制。此外，使用针对牙周病原体的蛋黄抗体进行被动免疫可能是治疗牙周炎的有效方法。需要进一步研究来评估这些生物牙菌斑控制方法对牙周病的可能影响。
Despite its important role in the control of periodontal disease, mechanical plaque control is not properly practiced by most individuals. Therefore, adjunctive chemical plaque control using chlorhexidine and antibiotics has also been suggested as an additional therapeutic strategy to augment mechanical plaque control. However, the additional effects of adjunctive antibiotic therapy are small, and topical chlorhexidine therapy is not without side effects. Given current limitations, new approaches for the control of biofilm are required. The new therapeutic approaches discussed in this review are divided into two categories: probiotics and vaccines. Probiotics is an interesting new field of periodontology research that aims to achieve biological plaque control by eliminating pathogenic bacteria. In addition, passive immunization using egg yolk antibody raised against periodontal pathogens may be an effective approach for the treatment of periodontitis. Further study to evaluate the possible effects of these biological plaque control methods against periodontal disease is warranted.