Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study
Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study
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胶原结合碱性成纤维细胞生长因子可改善子宫不孕妇女疤痕子宫内膜的功能重塑：一项试点研究。
DOI：
10.1007/s11427-018-9520-2
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发表时间：
2019-12-01
影响因子：
9.1
通讯作者：
Hu, Yali
中科院分区：
文献类型：
--
作者：
Jiang, Peipei;Tang, Xiaoqiu;Hu, Yali
子宫内膜粘连（IUA）是子宫内膜异位症的常见原因，其最严重的临床表现之一是子宫内膜纤维化，即子宫内膜瘢痕化，目前治疗方法较少。血管生成障碍是瘢痕子宫内膜的主要病理改变。成纤维细胞生长因子2（fibroblast growth factor 2，bFGF）是FGF家族的一员，常用于促进难治性溃疡的愈合，并有助于组织的血管生成。本研究在超声引导下，对18例患者瘢痕子宫内膜周围应用bFGF缓释系统100 μ g，每4周1次（2-4次）。结果显示，治疗后月经量、子宫内膜厚度、瘢痕子宫内膜面积均有所改善。组织学检查显示血管密度明显增加。3例患者（3/18）妊娠超过20周。因此，在瘢痕子宫内膜周围应用bFGF可能为子宫内膜纤维化患者提供一种新的治疗途径。
Intrauterine adhesion (IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2 (bFGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of bFGF 100 mu g was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients (2-4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved. Histological study showed blood vessel density increased obviously. Three patients (3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the bFGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis.