Environment dominates over host genetics in shaping human gut microbiota
Environment dominates over host genetics in shaping human gut microbiota
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DOI：
10.1038/nature25973
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发表时间：
2018-03-08
期刊：
影响因子：
64.8
通讯作者：
Segal, Eran
中科院分区：
文献类型：
--
作者：
Rothschild, Daphna;Weissbrod, Omer;Segal, Eran
人类肠道微生物组的组成受多种因素影响，但宿主遗传学的相对贡献仍然难以捉摸。在这里，我们检查了来自1,046名健康个体的基因型和微生物组数据，这些健康个体具有几个不同的祖先来源，他们共享一个相对共同的环境，并证明肠道微生物组与遗传祖先没有显着关联，宿主遗传学在决定微生物组组成方面起着次要作用。相比之下，我们发现，共享一个家庭的遗传无关个体的微生物组组成存在显着相似性，并且超过20%的人间微生物组变异性与饮食，药物和人体测量相关的因素有关。我们进一步证明，与仅使用宿主遗传和环境数据的模型相比，微生物组数据显着提高了许多人类特征的预测准确性，例如葡萄糖和肥胖指标。这些结果表明，旨在改善临床结果的微生物组改变可以在不同的遗传背景中进行。
Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.