Naltrexone treatment of adolescent alcoholics: An open-label pilot study
Naltrexone treatment of adolescent alcoholics: An open-label pilot study
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DOI：
10.1089/cap.2005.15.723
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发表时间：
2005-10-01
影响因子：
1.9
通讯作者：
Anton, R
中科院分区：
文献类型：
--
作者：
Deas, D;May, K;Anton, R
目的：这个为期6周的开放标签试验的纳曲酮进行了初步的方式，以确定是否纳曲酮将是安全的，耐受性良好，并导致减少酒精消费量的青少年酒精dependence.Method：五门诊寻求治疗的青少年谁符合精神疾病诊断和统计手册，第4版（DSM-IV）酒精依赖的标准被招募。精神分裂症和情感障碍的儿童时间表（K-SADS），DSM的结构化临床访谈。（SCID）和家族史问卷在基线时进行。在基线和此后每周进行时间线随访（TLFB）和两个渴望量表（青少年强迫性饮酒量表[A-OCDS]和渴望模拟量表）。每名受试者接受10天的纳洛酮（50 mg）和100 mg核黄素胶囊。受试者被指示采取纳曲酮和核黄素simultaneous.Results：总体而言，平均饮料每饮酒日（DDD）从基线到6周结束时，平均减少7.61标准饮料显着下降。平均A-OCDS总分、A-OCDS易激性子量表评分和渴望模拟评分显著降低。恶心是报告的唯一副作用，没有肝酶升高。纳洛酮是耐受良好的酒精依赖的adolescent.Conclusions：我们的数据表明，纳洛酮是安全的，耐受良好的青少年酗酒者。纳洛酮可能会导致青少年酗酒者的饮酒量和渴望显着减少，但需要更大的随机对照试验。
Objective: This 6-week open-label trial of naltrexone was conducted in a preliminary fashion to determine whether naltrexone would be safe, well tolerated, and lead to a reduction in alcohol consumption in adolescents with alcohol dependence.Method: Five outpatient treatment-seeking adolescents who met Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for alcohol dependence were recruited. The Child Schedule for Schizophrenia and Affective Disorders (K-SADS), Structured Clinical Interview for DSM. (SCID), and the Family History Questionnaire were administered at baseline. The Time-Line Follow-Back (TLFB) and two craving scales (Adolescent Obsessive Compulsive Drinking Scale [A-OCDS] and a craving analog scale) were administered at baseline and weekly thereafter. Each subject received a 10-day supply of naltrexone (50 mg) and a 100-mg riboflavin capsule. Subjects were instructed to take naltrexone and riboflavin simultaneously.Results: Overall, the average drinks per drinking day (DDD) decreased significantly from baseline to the end of week 6 with an average reduction of 7.61 standard drinks. There was a significant reduction in the average A-OCDS total score, A-OCDS Irresistibility subscale score, and craving analog score. Nausea was the only side-effect reported, and there were no elevations of liver enzymes. Naltrexone was well tolerated by the alcohol-dependent adolescent.Conclusions: Our data suggest that naltrexone is safe and well tolerated in adolescent alcoholics. Naltrexone may lead to a significant reduction in alcohol consumption and craving in adolescent alcoholics, but larger, randomized, controlled trials are needed.