Prefrontal CortexModulation during Anticipation ofWorking Memory Demands as Revealed by Magnetoencephalography
Prefrontal CortexModulation during Anticipation ofWorking Memory Demands as Revealed by Magnetoencephalography
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DOI：
10.1155/2010/840416
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发表时间：
2010-01-01
影响因子：
7.6
通讯作者：
Coppola, Richard
中科院分区：
文献类型：
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作者：
Altamura, Mario;Goldberg, Terry E.;Coppola, Richard
在预期任务需求的过程中，前向控制参与了基于当前目标的刺激-反应映射的组装。目前尚不清楚前额叶调制是否发生在较高级别的皮质区域，可能反映了认知预期过程。本论文的目的是研究脑磁图(MEG)显示的对即将到来的工作记忆需求的预测过程中的前额叶调制。20名健康志愿者在执行Sternberg工作记忆(WM)任务的同时进行了脑磁图检查。进行β波段(14~30赫兹)合成孔径磁学(SAM)分析。在准备期间，双侧背外侧前额叶皮质(DLPFC)、左侧前额下回、左侧顶叶和颞区的β功率(事件相关同步)增加。我们的结果支持了这样的假设，即在准备状态下，前额叶皮质对于偏向将要参与即将到来的任务的高级大脑区域是重要的。
During the anticipation of task demands frontal control is involved in the assembly of stimulus- response mappings based on current goals. It is not clear whether prefrontal modulations occur in higher-order cortical regions, likely reflecting cognitive anticipation processes. The goal of this paper was to investigate prefrontal modulation during anticipation of upcoming working memory demands as revealed by magnetoencephalography (MEG). Twenty healthy volunteers underwent MEG while they performed a variation of the Sternberg Working Memory (WM) task. Beta band (14-30 Hz) SAM (Synthetic Aperture Magnetometry) analysis was performed. During the preparatory periods there was an increase in beta power (event-related synchronization) in dorsolateral prefrontal cortex (DLPFC) bilaterally, left inferior prefrontal gyrus, left parietal, and temporal areas. Our results provide support for the hypothesis that, during preparatory states, the prefrontal cortex is important for biasing higher order brain regions that are going to be engaged in the upcoming task.