Seroprevalence of Toxoplasma gondii in northern Greece during the last 20 years
Seroprevalence of Toxoplasma gondii in northern Greece during the last 20 years
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DOI：
10.1111/j.1469-0691.2005.01193.x
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发表时间：
2005-09-01
影响因子：
14.2
通讯作者：
Antoniadis, A
中科院分区：
文献类型：
--
作者：
Diza, E;Frantzidou, F;Antoniadis, A
1984年、1994年和2004年在希腊北部人群中检测了弓形虫的血清阳性率，并调查了这三个时期的变化。1984年、1994年和2004年分别用标准免疫荧光法(IFA)和微粒子酶免疫法(MEIA)检测了1014、812和958份1日龄至70岁儿童血清中的弓形虫抗体。在IgM特异性抗体阳性的个体中，根据弓形虫血清学特征(IFA、MEIA、常规IgM和IgA ELISA、免疫吸附凝集试验和免疫球蛋白亲和力试验)诊断为弓形虫原发感染。1984年、1994年和2004年一般人群中特异性抗体的流行率分别为37%、29.9%和24.1%，育龄妇女(15~39岁)分别为35.6%、25.6%和20%。根据原发感染病例和普通人群年血清转换率估算，1984年弓形虫感染率为1.25%和1.1%，1994年为1.05%和0.93%，2004年为0.85%和0.8%。在此期间观察到的流行率的显著下降和向老年群体的转变可以用社会经济状况的改善来解释。育龄妇女易受弓形虫感染的比例很高(80%)，估计每年有90-200名新生儿在宫内感染，这似乎对公共卫生构成了潜在风险。对公众的教育和预防措施可能变得越来越重要。
The seroprevalence of Toxoplasma gondii in the northern Greek population was determined in 1984, 1994 and 2004, and changes during this period were investigated. In total, 1014, 812 and 958 sera from individuals aged 1 day to 70 years were examined in 1984, 1994 and 2004, respectively, for IgG and IgM anti-Toxoplasma antibodies with the standard immunofluorescence assay (IFA) and microparticle enzyme immunoassay (MEIA). In individuals positive for IgM-specific antibodies, primary infection with Toxoplasma was diagnosed on the basis of the Toxoplasma serological profile (IFA, MEIA, conventional IgM and IgA ELISAs, immunosorbent agglutination assay and IgG avidity test). The prevalence of IgG-specific antibodies in the general population was 37%, 29.9% and 24.1% in 1984, 1994 and 2004, respectively, and was 35.6%, 25.6% and 20%, respectively, in women of reproductive age (15-39 years). The incidence of Toxoplasma infection, based on cases of primary infection and the annual seroconversion rate for the general population, was estimated to be 1.25% and 1.1% in 1984, 1.05% and 0.93% in 1994, and 0.85% and 0.8% in 2004. The significant decline in prevalence, and the shift towards an older age group, observed during this period could be explained by the improved socio-economic situation. The high (80%) proportion of women of reproductive age susceptible to Toxoplasma infection, with an estimated 90-200 neonates infected in utero annually, seems to present a potential risk to public health. Education of the public and prophylactic measures may become increasingly important.