Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context?
Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context?
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DOI：
10.1172/jci22309
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发表时间：
2004-07
期刊：
影响因子：
--
通讯作者：
J. Curci;Robert W. Thompson
中科院分区：
文献类型：
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作者：
J. Curci;Robert W. Thompson
Abdominal aortic aneurysms are common and life threatening. Although CD4(+) T cells are abundant in aneurysm tissue, their role in disease progression remains unclear. A new study shows that mouse aortic allografts placed in animals lacking IFN-gamma receptors develop a Th2 inflammatory response with aortic aneurysms, whereas Th1 responses promote intimal hyperplasia. It is expected that these surprising findings will stimulate further efforts to clarify whether adaptive cellular immunity in aneurysm disease is detrimental or potentially beneficial.
