Selection, integration, and conflict monitoring: Assessing the nature and generality of prefrontal cognitive control mechanisms
Selection, integration, and conflict monitoring: Assessing the nature and generality of prefrontal cognitive control mechanisms
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DOI：
10.1016/s0896-6273(03)00851-1
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发表时间：
2004-02-05
期刊：
影响因子：
16.2
通讯作者：
Wagner, AD
中科院分区：
文献类型：
--
作者：
Badre, D;Wagner, AD
前额叶皮层（PFC）通过调节认知控制来支持灵活的行为，尽管PFC支持的基本控制形式仍然是一个中心争论。背外侧前额叶皮层（DLPFC）被认为是指导反应冲突条件下的反应选择，或者，可刷新最近在工作记忆中的积极表征。外侧额极皮层（FPC）也可能裁定反应冲突，尽管其他人认为FPC支持更高阶的控制过程，如subgoaling和整合。前扣带皮层（ACC）被假设为通过检测反应冲突来上调反应选择;目前尚不清楚ACC功能是否超出了监测反应冲突。本fMRI实验直接测试这些竞争的理论DLPFC，FPC，和ACC. Results的功能作用揭示分离的控制过程中PFC，与中期DLPFC选择性地介导的反应冲突和FPC进一步调解subgoaling/整合的决议。ACC表现出广泛的敏感性，控制需求，这表明在调制认知控制的广义作用。
Prefrontal cortex (PFC) supports flexible behavior by mediating cognitive control, though the elemental forms of control supported by PFC remain a central debate. Dorsolateral PFC (DLPFC) is thought to guide response selection under conditions of response conflict or, alternatively, may refresh recently active representations within working memory. Lateral frontopolar cortex (FPC) may also adjudicate response conflict, though others propose that FPC supports higher order control processes such as subgoaling and integration. Anterior cingulate cortex (ACC) is hypothesized to upregulate response selection by detecting response conflict; it remains unclear whether ACC functions generalize beyond monitoring response conflict. The present fMRI experiment directly tested these competing theories regarding the functional roles of DLPFC, FPC, and ACC. Results reveal dissociable control processes in PFC, with mid-DLPFC selectively mediating resolution of response conflict and FPC further mediating subgoaling/integration. ACC demonstrated a broad sensitivity to control demands, suggesting a generalized role in modulating cognitive control.