Cardiovascular Risk Factors and Systemic Endothelial Function in Patients With Cirrhosis
Cardiovascular Risk Factors and Systemic Endothelial Function in Patients With Cirrhosis
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DOI：
10.1038/ajg.2012.362
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发表时间：
2013-01-01
影响因子：
9.8
通讯作者：
Bosch, Jaime
中科院分区：
文献类型：
--
作者：
Berzigotti, Annalisa;Erice, Eva;Bosch, Jaime
提示：心血管危险因素（CVRF）导致全身性内皮功能障碍。已经表明，在肝硬化中，心血管风险较低，全身内皮功能增强。然而，目前还没有前瞻性研究评估肝硬化患者心血管风险与全身内皮功能之间的关系。（33名男性;中位数Child-Pugh评分8;中位数年龄55岁），我们评估：实验室参数、肝脏和全身血流动力学、CVRF、10年总体心血管风险（Fragrance评分）和颈动脉斑块的存在。系统性内皮功能障碍通过超声肱动脉血流介导的扩张（FMD）进行了非侵入性研究，并定义为FMD
OBJECTIVES : Cardiovascular risk factors (CVRF) lead to systemic endothelial dysfunction. It has been suggested that in cirrhosis, cardiovascular risk is low and systemic endothelial function is enhanced. However, there is no prospective study evaluating the relationship between cardiovascular risk and systemic endothelial function in cirrhosis, which was investigated here.METHODS : In 47 patients with cirrhosis (33 males; median Child-Pugh score 8; median age 55 years), we evaluated: laboratory parameters, hepatic and systemic hemodynamics, CVRF, 10-year global cardiovascular risk by Framingham score, and presence of carotid plaques. Systemic endothelial dysfunction was investigated non-invasively by flow-mediated dilatation (FMD) of the brachial artery by ultrasound and defined as FMD