PARALLEL CARDIAC AND VASCULAR ADAPTATION IN HYPERTENSION
PARALLEL CARDIAC AND VASCULAR ADAPTATION IN HYPERTENSION
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DOI：
10.1161/01.cir.86.6.1909
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发表时间：
1992-12-01
期刊：
影响因子：
37.8
通讯作者：
DEVEREUX, RB
中科院分区：
文献类型：
--
作者：
ROMAN, MJ;SABA, PS;DEVEREUX, RB
背景虽然在非冠状动脉循环血管损伤是高血压并发症的一个主要原因，在体内的几何形状和功能的动脉循环在无并发症的高血压患者或他们的关系，左心室肥厚，心血管并发症的风险增加的标志物是相对知之甚少。通过超声测定43例无症状高血压患者和43例血压正常者的颈总动脉壁厚度和内径，以及颅外颈动脉内是否存在动脉粥样硬化。血管硬度估计同时叠加颈动脉压力波形获得与外部固态传感器。超声心动图测定左心室大小和功能。与正常人相比，高血压患者的左室绝对和相对壁厚、左室质量、颈动脉绝对和相对壁厚均显著增加（p
Background. Although vascular damage in the noncoronary circulation is a major cause of complications in hypertension, relatively little is known of the in vivo geometry and function of the arterial circulation in patients with uncomplicated hypertension or of their relation to left ventricular hypertrophy, a marker of enhanced risk of cardiovascular complications.Methods and Results. Wall thickness and internal diameter of the common carotid artery and the presence of atherosclerosis within the extracranial carotid arteries were determined by ultrasound in 43 asymptomatic hypertensive patients and 43 normotensive subjects matched for sex, age, and body size. Vascular stiffness was estimated from simultaneous superimposed carotid pressure waveforms obtained with an external solid-state transducer. Left ventricular size and function were determined echocardiographically. Compared with normal subjects, hypertensive patients had greater left ventricular absolute and relative wall thicknesses, left ventricular mass, and carotid absolute and relative wall thicknesses (p