Mycoplasma bovis pneumonia in cattle
Mycoplasma bovis pneumonia in cattle
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DOI：
10.1017/s1466252307001351
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发表时间：
2007-12-01
影响因子：
2.5
通讯作者：
Archambault, Marie
中科院分区：
文献类型：
--
作者：
Caswell, Jeff L.;Archambault, Marie
牛支原体是饲养场牛、乳牛和小牛犊呼吸道疾病和关节炎的重要和新出现的病因，并且在牛中具有多种其他疾病表现。M.牛病毒当然能够引起牛只的急性呼吸道疾病，但其可归因的比例却难以估计。相比之下，M。牛更容易被认为是慢性支气管扩张症的病因，伴有干酪样坏死和凝固性坏死，其特征是对许多抗生素反应不良的持续感染。通过比较自然和实验诱导的疾病，分子诊断工具的发展，以及对毒力的某些方面的了解，最近对该疾病的理解有所进展，但有关保护性免疫，基因型多样性的重要性，毒力机制和共同病原体的作用的不确定性限制了我们对发病机制的理解和我们有效控制该疾病的能力。本文对M.牛感染和牛呼吸道疾病综合征的各种表现，并解决了发病机制，临床和病理后遗症，实验室诊断和控制的疾病造成的M。牛的呼吸道感染。
Mycoplasma bovis is an important and emerging cause of respiratory disease and arthritis in feedlot cattle and young dairy and veal calves, and has a variety of other disease manifestations in cattle. M. bovis is certainly capable of causing acute respiratory disease in cattle, yet the attributable fraction has been difficult to estimate. In contrast, M. bovis is more accepted as a cause of chronic bronchopneumonia with caseous and perhaps coagulative necrosis, characterized by persistent infection that seems poorly responsive to many antibiotics. An understanding of the disease has been recently advanced by comparisons of natural and experimentally induced disease, development of molecular diagnostic tools, and understanding some aspects of virulence, yet uncertainties regarding protective immunity, the importance of genotypic diversity, mechanisms of virulence, and the role of co-pathogens have restricted our understanding of pathogenesis and our ability to effectively control the disease. This review critically considers the relationship between M. bovis infection and the various manifestations of the bovine respiratory disease complex, and addresses the pathogenesis, clinical and pathologic sequelae, laboratory diagnosis and control of disease resulting from M. bovis infection in the bovine respiratory tract.