Understanding the Role of Plasma Bullet Currents in Heating Skin to Mitigate Risks of Thermal Damage Caused by Low-Temperature Atmospheric-Pressure Plasma Jets-猫眼课题宝

DOI：

10.3390/plasma6010009

发表时间：

2023-02

期刊：

Plasma

影响因子：

通讯作者：

中科院分区：

文献类型：

作者：

Shunya Hashimoto;H. Fukuhara;E. Szili;C. Kawada;Sung-Ha Hong;Yuta Matsumoto;T. Shirafuji;Masayuki Ts

低温常压等离子射流通常被认为是一种安全的医疗技术，在迄今为止报道的临床研究中没有明显的长期副作用。然而，有研究表明，等离子射流在某些条件下会引起严重的副作用，如皮肤烧伤。因此，为了开发更安全的等离子体治疗方法，在这项研究中，我们着手对这些皮肤烧伤的原因以及如何调整等离子体治疗以减轻这些影响提供新的见解。我们发现，在对活体小鼠进行氦等离子体射流治疗期间，等离子体子弹电流产生的焦耳热导致皮肤烧伤。通过在更远的距离处治疗小鼠，使可见的血浆羽流不接触皮肤，可以减轻这些烧伤。在这些治疗条件下，我们还表明，等离子射流治疗仍然保留了其在体内产生活性氧的医学有益特性。因此，治疗距离是评估医用血浆治疗安全性时需要考虑的重要参数。

Low-temperature atmospheric-pressure plasma jets are generally considered a safe medical technology with no significant long-term side effects in clinical studies reported to date. However, there are studies emerging that show plasma jets can cause significant side effects in the form of skin burns under certain conditions. Therefore, with a view of developing safer plasma treatment approaches, in this study we have set out to provide new insights into the cause of these skin burns and how to tailor plasma treatments to mitigate these effects. We discovered that joule heating by the plasma bullet currents is responsible for creating skin burns during helium plasma jet treatment of live mice. These burns can be mitigated by treating the mice at a further distance so that the visible plasma plume does not contact the skin. Under these treatment conditions we also show that the plasma jet treatment still retains its medically beneficial property of producing reactive oxygen species in vivo. Therefore, treatment distance is an important parameter for consideration when assessing the safety of medical plasma treatments.

Understanding the Role of Plasma Bullet Currents in Heating Skin to Mitigate Risks of Thermal Damage Caused by Low-Temperature Atmospheric-Pressure Plasma Jets

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