Association Between Maternal Adverse Childhood Experiences and Neonatal SCG5 DNA Methylation-Effect Modification by Prenatal Home Visiting
Association Between Maternal Adverse Childhood Experiences and Neonatal SCG5 DNA Methylation-Effect Modification by Prenatal Home Visiting
复制标题
DOI：
10.1093/aje/kwab270
复制
发表时间：
2022-01-13
影响因子：
5
通讯作者：
Bowers, Katherine A.
中科院分区：
文献类型：
--
作者：
Folger, Alonzo T.;Nidey, Nichole;Bowers, Katherine A.
母亲童年时期的逆境和创伤可能会引发生物变化，通过 DNA 甲基化 (DNAm) 测量的表观遗传反应影响下一代。这些表观遗传关联可以通过保护性因素被产后早期环境所改变，例如旨在减轻逆境的有害代际影响的幼儿期家访（HV）计划。在 2015 年至 2016 年妊娠和婴儿发育研究（俄亥俄州辛辛那提）招募的 53 对母子队列中，我们研究了母亲不良童年经历 (ACE) 与新生儿分泌颗粒 V 基因 (SCG5) 中 DNAm 之间的关联，该基因对神经内分泌功能很重要。我们检查了产前 HV 作为一种效应调节剂。母亲在怀孕期间完成了关于 ACE 的调查问卷，并在产后 1 个月收集了婴儿口腔样本。使用多变量线性回归来检查母体 ACE 和新生儿 DNAm 之间的关联，表达为 4 个胞嘧啶-磷酸-鸟嘌呤二核苷酸位点的平均 M 值。母亲 ACE 数量较高 (>3) 与后代 DNAm 降低 5.79 个百分点相关（95% 置信区间：-10.44，-1.14），并且这种关联会根据怀孕期间接受的家访次数进行修改。在高危母子二人群体中，初步证据表明，母体 ACE 与后代 SCG5 DNAm 存在相关性，其差异在于产前 HV 的量。
Maternal childhood adversity and trauma may elicit biological changes that impact the next generation through epigenetic responses measured in DNA methylation (DNAm). These epigenetic associations could be modified by the early postnatal environment through protective factors, such as early childhood home visiting (HV) programs that aim to mitigate deleterious intergenerational effects of adversity. In a cohort of 53 mother-child pairs recruited in 2015-2016 for the Pregnancy and Infant Development Study (Cincinnati, Ohio), we examined the association between maternal adverse childhood experiences (ACEs) and neonatal DNAm in the secretogranin V gene (SCG5), which is important in neuroendocrine function. We examined prenatal HV as an effect modifier. Mothers completed a questionnaire on ACEs during pregnancy, and infant buccal samples were collected 1 month postpartum. Multivariable linear regression was used to examine the association between maternal ACEs and neonatal DNAm expressed as M-values averaged across 4 cytosine-phosphate-guanine dinucleotide sites. A higher number of maternal ACEs (>3) was associated with a 5.79-percentage-point lower offspring DNAm (95% confidence interval: -10.44, -1.14), and the association was modified by the number of home visits received during pregnancy. In a population of at-risk mother-child dyads, preliminary evidence suggests that maternal ACEs have a relationship with offspring SCG5 DNAm that differs by the amount of prenatal HV.