Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys
Calcium Transient Dynamics of Neural Ensembles in the Primary Motor Cortex of Naturally Behaving Monkeys
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DOI：
10.1016/j.celrep.2018.07.057
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发表时间：
2018-08-21
期刊：
影响因子：
8.8
通讯作者：
Okano, Hideyuki
中科院分区：
文献类型：
--
作者：
Kondo, Takahiro;Saito, Risa;Okano, Hideyuki
为了了解自然条件下认知行为的大脑回路，我们开发了对自然行为的普通绒猴深层皮质中的大量神经元群体的神经元活动进行成像的技术。动物取回食物颗粒或爬梯子，微型荧光显微镜监测右侧初级运动皮质中数百个表达钙指示剂的皮质神经元。这项技术可以适用于其他大脑区域，通过促进与认知自然主义行为及其病理生理过程相关的神经元表征的纵向种群分析，可以加深我们对大脑回路的理解。
To understand brain circuits of cognitive behaviors under natural conditions, we developed techniques for imaging neuronal activities from large neuronal populations in the deep layer cortex of the naturally behaving common marmoset. Animals retrieved food pellets or climbed ladders as a miniature fluorescence microscope monitored hundreds of calcium indicator-expressing cortical neurons in the right primary motor cortex. This technique, which can be adapted to other brain regions, can deepen our understanding of brain circuits by facilitating longitudinal population analyses of neuronal representation associated with cognitive naturalistic behaviors and their pathophysiological processes.