Hepatitis C virus-host interactions, replication, and viral assembly.
Hepatitis C virus-host interactions, replication, and viral assembly.
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DOI：
10.1016/j.coviro.2012.09.013
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发表时间：
2012-12
影响因子：
5.9
通讯作者：
Randall, Glenn
中科院分区：
文献类型：
--
作者：
Shulla, Ana;Randall, Glenn
丙型肝炎病毒（HCV）是一种相对简单的病毒，其感染、复制和传播广泛依赖于宿主。HCV已经进化出宿主相互作用，导致在细胞类型和物种方面的限制性向性。鉴定和验证HCV-宿主相互作用的努力受到有限数量的支持HCV感染的感染性病毒克隆和细胞系的阻碍。尽管有这些限制，共识HCV-宿主相互作用已经出现，有助于定义HCV的进入，复制，组装和嗜性。这对扩大我们的体外和体内系统研究HCV复制和发病机制具有重要意义。此外，这些宿主因子中的一些正被靶向用于治疗开发。在这篇综述中，我们重点关注医学相关的前病毒宿主因子，它们在HCV生物学中的作用，以及它们在扩展我们的模型系统中的重要性。
As a relatively simple virus, hepatitis C virus (HCV) depends extensively on its host to infect, replicate and disseminate. HCV has evolved host interactions that result in a restricted tropism, both in terms of cell type and species. Efforts into identifying and validating HCV-host interactions have been hampered by a limited number of infectious virus clones and cell lines that support HCV infection. Despite these limitations, consensus HCV-host interactions have emerged that help define the entry, replication, assembly, and tropism of HCV. This has had important implications in expanding our in vitro and in vivo systems to study HCV replication and pathogenesis. Additionally, a number of these host factors are being targeted for therapeutic development. In this review, we focus on medically relevant pro-viral host factors, their role in HCV biology, and their importance in expanding our model systems.
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