Recent advances in understanding HIV evolution.
Recent advances in understanding HIV evolution.
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DOI：
10.12688/f1000research.10876.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Rowland-Jones S
中科院分区：
文献类型：
--
作者：
Andrews SM;Rowland-Jones S
人类免疫缺陷病毒（HIV）由于易出错的逆转录酶的联合活性、重组和较短的生成时间而迅速进化，导致宿主内部和宿主之间广泛的病毒多样性。这种多样性是导致免疫系统无法根除病毒的一个主要因素，并对开发对抗感染的合适药物和疫苗具有重要意义。本综述将讨论揭示艾滋病毒演变的最新技术进展，并将总结这一领域的新概念。
The human immunodeficiency virus (HIV) evolves rapidly owing to the combined activity of error-prone reverse transcriptase, recombination, and short generation times, leading to extensive viral diversity both within and between hosts. This diversity is a major contributing factor in the failure of the immune system to eradicate the virus and has important implications for the development of suitable drugs and vaccines to combat infection. This review will discuss the recent technological advances that have shed light on HIV evolution and will summarise emerging concepts in this field.