High expression of transcriptional factor HoxB9 predicts poor prognosis in patients with lung adenocarcinoma
High expression of transcriptional factor HoxB9 predicts poor prognosis in patients with lung adenocarcinoma
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DOI：
10.1111/his.12585
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发表时间：
2015-06-01
期刊：
影响因子：
6.4
通讯作者：
Zhang, Hongquan
中科院分区：
文献类型：
--
作者：
Zhan, Jun;Wang, Peng;Zhang, Hongquan
AimsHoxB 9作为Hox家族成员，在胚胎发育过程中发挥重要作用。最近的研究表明，HoxB 9参与了癌症的进展。然而，Hoxb 9在肺腺癌中的作用尚不清楚。本研究旨在探讨HoxB 9在肺腺癌组织中的表达及其与预后的关系。通过Kaplan-Meier分析评估HoxB 9表达水平与患者存活率之间的相关性。检测HoxB 9表达上调和下调的H1299肺腺癌细胞的上皮-间质转化（EMT）标志物和迁移能力。HoxB 9主要定位于细胞核，在21.3%的肺腺癌中表达。HoxB 9在高分期肺腺癌中表达强度明显增高（P
AimsHoxB9, as a Hox family member, is known to play important roles in embryonic development. Recent studies showed that HoxB9 is engaged in cancer progression. However, the role of Hoxb9 in lung adenocarcinoma is unknown. The purpose of this study is to investigate the expression and prognostic value of HoxB9 in patients with lung adenocarcinoma.Methods and resultsThe localization and expression of HoxB9 in lung adenocarcinoma were examined byimmunohistochemistry. The correlation between HoxB9 expression levels with patient survival was assessed by Kaplan-Meier analysis. The epithelial-mesenchymal transition (EMT) markers and migratory ability were evaluated in HoxB9 up- and down-regulated H1299 lung adenocarcinoma cells. HoxB9 was found to be localized predominantly in the cell nuclei and expressed in 21.3% of lung adenocarcinomas. Asignificant increase in HoxB9 intensity in the highstage of lung adenocarcinoma was observed (P