A pilot, two-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic kneel
A pilot, two-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic kneel
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DOI：
10.1016/j.joca.2004.09.001
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发表时间：
2004-12-01
影响因子：
7
通讯作者：
Majumdar, S
中科院分区：
文献类型：
--
作者：
Blumenkrantz, G;Lindsey, CT;Majumdar, S
目的：应用磁共振成像技术研究不同程度骨关节炎(OA)患者骨小梁与软骨结构变化的关系。方法：采用三维快速梯度回波序列，获取高分辨率的轴位图像，评价骨小梁结构。高分辨率、脂肪抑制的矢状位图像用于评估软骨结构，使用3-D破坏的梯度回波序列。在一组患者中，使用二维双回波自旋回波序列采集矢状面图像来测量T-2松弛时间。结果：在每组受试者中，骨和软骨参数有很大的差异，然而，在骨关节炎受试者(尤其是轻度骨性关节炎受试者)中，特定组别的平均值显示出(骨和软骨参数)下降的趋势。除胫骨外侧外，所有软骨室的平均T-2在基线和随访检查之间显著增加(P<；0.05)。软骨改变与最靠近关节线的局部骨改变呈正相关，而与距关节线最远的全局性骨改变呈负相关。结论：本研究量化了骨和软骨结构参数随时间的变化，并证实了不同程度的骨性关节炎患者骨和软骨结构的形态变化之间存在纵向关系。虽然骨和软骨的变化在受试者中有很大的差异，但在样本量相对较小、随访时间较短的情况下，明显的趋势是明显的。(C)2004年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: To examine the relationship between structural changes of trabecular bone and cartilage, in patients with varying degrees of osteoarthritis (OA) over 2 years, using magnetic resonance imaging.Methods: High-resolution, axial images were acquired for assessing trabecular bone structure, using a 3-D fast gradient-echo sequence. High-resolution, fat-suppressed, sagittal images were acquired for assessing cartilage structure, using a 3-D spoiled gradient-echo sequence. In a subset of the patients, sagittal images were acquired for measuring T-2 relaxation time, using a 2-D dual-echo spin echo sequence.Results: A large variation in bone and cartilage parameters is evident among individual subjects in each group, however, group-specific means demonstrate decreasing trends (in bone and cartilage parameters) in osteoarthritic subjects (especially in mild OA subjects). The mean T-2 increased significantly (P < 0.05) between the baseline and follow-up exams for all cartilage compartments except the lateral tibia. A positive relationship was established between cartilage changes and localized bone changes closest to the joint line, while a negative relationship was established between cartilage changes and global bone changes farthest from the joint line.Conclusion: This study quantifies the changes in bone and cartilage structural parameters over time, and demonstrates a longitudinal relationship between the morphological changes in bone and cartilage structure in patients with varying degrees of OA. Although a large variation of bone and cartilage changes is apparent among subjects, significant trends are evident in a relatively small sample size, with a short follow-up duration. (C) 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.