Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma.
Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma.
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人T淋巴细胞的分化：II．
DOI：
10.1111/1523-1747.ep12507406
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Jegasothy,BV
中科院分区：
文献类型：
--
作者：
Haynes,BF;Hensley,LL;Jegasothy,BV
本文研究了皮肤T细胞淋巴瘤患者循环和皮肤恶性T细胞的细胞表面抗原表型。恶性T细胞的成熟T细胞抗原表型与循环和皮肤恶性T细胞相同。相反，皮肤恶性T细胞表达未成熟的人T细胞抗原Thy-1、表面膜转铁蛋白受体和Ia样决定簇，而循环恶性T细胞不表达这些抗原。良性皮肤病中的皮肤浸润T细胞也表达Thy-1和Ia样决定簇。这些观察结果支持了皮肤是胸腺外T细胞分化的主要部位的观点，并可能促进归巢皮肤的循环T细胞的表型变化。
The cell surface antigen phenotype of circulating and skin malignant T-cells in patients with cutaneous T-cell lymphoma were studied. The mature T-cell antigen phenotype of the malignant T-cells was identical for circulating and skin malignant T-cells. In contrast, skin malignant T-cells expressed the immature human T-cell antigen Thy-1, surface membrane transferrin receptors, and Ia-like determinants while circulating malignant T- cells did not express these antigens. Skin infiltrating T-cells in benign dermatoses also expressed Thy-1 and Ia- like determinants. These observations support the notion that the skin is a major site of extrathymic T-cell differentiation and may promote phenotypic changes in circulating T-cells that home to skin.