Micro Optical Coherence Tomography for Coronary Imaging.
Micro Optical Coherence Tomography for Coronary Imaging.
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DOI：
10.3389/fcvm.2021.613400
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发表时间：
2021
影响因子：
3.6
通讯作者：
Tearney G
中科院分区：
文献类型：
--
作者：
Nishimiya K;Tearney G
血管内光学相干断层扫描（IVOCT）可产生分辨率为10 μm的图像，已成为评价冠状动脉结构形态的重要技术。然而，许多与冠状动脉斑块发病机制相关的特征只能在细胞水平上看到。这个问题促使开发提供更高分辨率的下一代OCT成像形式。我们在这里回顾的一种技术称为微型OCT（μOCT），它可以评估人类冠状动脉粥样硬化斑块的细胞和亚细胞形态。本章回顾了心脏病学领域中μOCT的最新进展和正在进行的工作。这项新技术有可能为研究人员和临床医生提供一种工具，以更好地了解冠状动脉粥样硬化的自然史，提高斑块进展预测能力，并更好地评估血运重建治疗后的血管愈合过程。
Intravascular optical coherence tomography (IVOCT) that produces images with 10 μm resolution has emerged as a significant technology for evaluating coronary architectural morphology. Yet, many features that are relevant to coronary plaque pathogenesis can only be seen at the cellular level. This issue has motivated the development of a next-generation form of OCT imaging that offers higher resolution. One such technology that we review here is termed micro-OCT (μOCT) that enables the assessment of the cellular and subcellular morphology of human coronary atherosclerotic plaques. This chapter reviews recent advances and ongoing works regarding μOCT in the field of cardiology. This new technology has the potential to provide researchers and clinicians with a tool to better understand the natural history of coronary atherosclerosis, increase plaque progression prediction capabilities, and better assess the vessel healing process after revascularization therapy.