Different transitions of multifocal electroretinogram recordings between patients with age-related macular degeneration and polypoidal choroidal vasculopathy after photodynamic therapy
Different transitions of multifocal electroretinogram recordings between patients with age-related macular degeneration and polypoidal choroidal vasculopathy after photodynamic therapy
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DOI：
10.1136/bjo.2006.092783
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发表时间：
2006-07
影响因子：
4.1
通讯作者：
H. Imai;S. Honda;Y. Nakanishi;H. Yamamoto;Y. Tsukahara;A. Negi
中科院分区：
文献类型：
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作者：
H. Imai;S. Honda;Y. Nakanishi;H. Yamamoto;Y. Tsukahara;A. Negi
目的：采用多焦视网膜电图（mfERG）比较和评价年龄相关性黄斑变性（AMD）和息肉状脉络膜血管病（PCV）在光动力治疗（PDT）后视网膜功能的转变。方法：10只眼AMD继发脉络膜新生血管（CNV），11只眼PCV继发CNV。分别于PDT前、PDT后1周和3个月记录mfERG。mfERG记录通过Veris系统（V.3.1.3）使用103六边形刺激获得。一阶核用于计算振幅和振幅。分析了从0-4°视角的两个中央环获得的平均振幅和振幅，并与每种疾病进行比较。结果如下：在AMD中，PDT后1周，平均第一负峰（N1）振幅趋于降低，平均第一正峰（N1 P1）振幅降低至显著水平（p = 0.047）。PDT后3个月，与PDT前值相比，平均N1和N1 P1振幅无显著差异。在PCV中，治疗后1周平均N1和N1 P1振幅无显著变化。然而，PDT后3个月，与PDT前值相比，平均振幅显示N1（p = 0.008）和N1 P1（p = 0.006）振幅显著增加。结论：AMD和PCV患者的mfERG记录转换存在差异。在AMD患者中，这些结果可能显示PDT后1周视网膜功能的短暂损害，但在PCV患者中，PDT的疗效上级PDT后的损害。
Aim: To compare and evaluate the transitions in retinal function after photodynamic therapy (PDT) between age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) using multifocal electroretinograms (mfERGs). Methods: 10 eyes with choroidal neovascularisation (CNV) secondary to AMD and 11 eyes with CNV secondary to PCV were included in the study. mfERGs were recorded before PDT, and 1 week and 3 months after PDT. mfERG recordings were acquired by a Veris system (V.3.1.3) using a 103 hexagon stimulus. The first-order kernel was used to calculate amplitudes and latencies. Mean amplitudes and latencies from two central rings rated 0–4° of visual angle were analysed and compared with each disease. Results: In AMD, the mean first negative peak (N1) amplitudes tended to decrease, and the mean first positive peak (N1P1) amplitudes reduced to significant levels (p = 0.047) 1 week after PDT. 3 months after PDT, there were no significant differences in the mean N1 and N1P1 amplitudes compared with pre-PDT values. In PCV, there were no significant changes in the mean N1 and N1P1 amplitudes 1 week after treatment. However, 3 months after PDT, mean amplitudes showed significant increases in N1 (p = 0.008) and N1P1 (p = 0.006) amplitudes compared with pre-PDT values. Conclusions: mfERG recording transitions are different between patients with AMD and those with PCV. In patients with AMD, these results may show transient impairments in retinal function 1 week after PDT, but in those with PCV, the efficacy of PDT is superior to the impairment after PDT.