Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation
Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation
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DOI：
10.1007/s00380-017-1003-6
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发表时间：
2017-11-01
影响因子：
1.5
通讯作者：
Isobe, Mitsuaki
中科院分区：
文献类型：
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作者：
Aoyama, Norio;Suzuki, Jun-ichi;Isobe, Mitsuaki
外周动脉疾病（PAD）是肢体动脉狭窄的常见表现，可减少动脉血流。虽然牙周炎患者患PAD的风险很高，但迄今为止几乎没有提供因果关系的信息。为了澄清这种关系，我们进行了这项横断面研究。评价了在东京医科齿科大学医院就诊的PAD患者的口腔状况。进行血液检查和牙科临床测量，包括牙齿数量、探诊袋深度（PPD）、探诊出血（BOP）和临床附着水平（CAL）。采用卡方检验比较性别、吸烟率、糖尿病、高血压、血脂异常患病率和无牙率。使用Wilcoxon检验比较细菌计数和抗细菌抗体，使用Student t检验比较其他数值。受试者为患有（n = 34）或未患有（n = 956）PAD的患者。我们发现PAD患者比非PAD患者有更多的缺牙（17.5 +/- 11.0），更高的缺牙率（18%）和更高的血清炎症因子水平（分别为10.9 +/- 8.7，5%）。另一方面，两组之间的高血压、血脂异常、吸烟状况、HbA 1c、细菌抗体滴度和细菌计数无显著差异。总之，我们阐明了PAD患者的牙齿数量减少，口腔和牙周状况恶化，全身炎症增强。
Peripheral arterial disease (PAD) is a common manifestation of arterial stenosis of the extremity that reduces arterial flow. While patients with periodontitis are at a high risk of PAD, little causal information has been provided to date. To clarify the relationship, we conducted this cross-sectional study. The oral condition of patients with or without PAD, who attended Tokyo Medical and Dental University Hospital, was evaluated. Blood examinations and dental clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) were performed. Chi-square test was performed to compare gender, smoker rate, prevalence of DM, hypertension and dyslipidemia and edentulous rate. Wilcoxon test was used to compare bacterial counts and anti-bacterial antibodies and Student's t test was used to compare the other numerical values. The subjects were patients with (n = 34) or without (n = 956) PAD. We revealed that the PAD patients had more missing teeth (17.5 +/- 11.0), a higher rate of edentulism (18%), and higher serum inflammatory factor levels than non-PAD patients (10.9 +/- 8.7, 5%, respectively). On the other hand, there was no significant difference between hypertension, dyslipidemia, smoking status, HbA1c, bacterial antibody titers, and bacterial counts between the groups. In conclusion, we clarified that PAD patients had decreased tooth number and worsened oral and periodontal condition with enhanced systemic inflammation.