Comparison of aqueous humor levels of PlGF and VEGF in proliferative diabetic retinopathy before and after intravitreal conbercept injection
Comparison of aqueous humor levels of PlGF and VEGF in proliferative diabetic retinopathy before and after intravitreal conbercept injection
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DOI：
10.1016/j.diabres.2020.108083
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发表时间：
2020-04-01
影响因子：
5.1
通讯作者：
Dai, Rong-ping
中科院分区：
文献类型：
--
作者：
Zhang, Xiao;Wu, Jie;Dai, Rong-ping
目的：目的：观察增生性糖尿病视网膜病变（proliferative diabetic retinopathy，PDR）患者玻璃体腔注射康柏西普（conbercept）前、后1周房水中胎盘生长因子（plantation growth factor，PlGF）和血管内皮生长因子（vascular endothelial growth factor，VEGF）水平的变化。所有患者均接受0.5 mg conbercept玻璃体内注射，1周后进行玻璃体切除术。结果：在注射康柏西普前，眼房水中VEGF-A、VEGF-B和PlGF的中位数分别为457：0 pg/mL oIQR（392：9 ~ 860：6 pg/mLTHORN）、43：6 pg/mL oIQR（33：6 ~ 81：6 pg/mLTHORN）和37：5 pg/mL oIQR（25：0 ~ 53：6 pg/mLTHORN）。注射康柏西普1周后，房水VEGF-A、VEGF-B和PiGF水平显著降低。有纤维血管膜的PDR患者房水VEGF-A水平低于无纤维血管膜的PDR患者。房水VEGF-B与PiGF水平呈正相关（P = 0.007）。VEGF-A和PiGF水平之间无显著相关性。结论：活动性PDR患者玻璃体内注射康柏西普后，房水中PlGF水平与VEGF-B相关，VEGF-A、VEGF-B和PlGF水平降低。(C)2020 Elsevier B. V.保留所有权利。
Aims: The aim of this paper is to observe the change of aqueous humor levels of placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR) patients before and one week after intravitreal conbercept injection.Methods: A prospective case series study was conducted in 24 active PDR patients (24 eyes). All the patients had received 0.5 mg of intravitreal conbercept followed by vitrectomy one week later. The aqueous humor was collected before conbercept injection and at the beginning of vitrectomy.Results: Before conbercept injection, the aqueous humor median levels of VEGF-A, VEGF-B and PlGF were 457:0 pg/mL oIQR from 392:9 to 860:6 pg/mLTHORN, 43:6 pg/mL oIQR from 33:6 to 81:6 pg/mLTHORN, 37:5 pg/mL oIQR from 25:0 to 53:6 pg/mLTHORN, respectively. One week after conbercept injection, the aqueous humor levels of VEGF-A, VEGF-B and PiGF decreased significantly. The aqueous humor VEGF-A levels in PDR patients with fibrovascular membraneswere lower than those without them. Therewaspositive correlation between aqueous humor VEGF-B and PiGF levels (P = 0.007). No significant correlation was found between VEGF-A and PiGF levels. No ocular and systemic adverse events were observed.Conclusions: The aqueous humor levels of PlGF was correlated with VEGF-B, and levels of VEGF-A, VEGF-B, and PlGF decreased after intravitreal conbercept injection in active PDR patients. (C) 2020 Elsevier B.V. All rights reserved.