A case of cholestatic hepatitis associated with histologic features of acute cholangitis
A case of cholestatic hepatitis associated with histologic features of acute cholangitis
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伴有急性胆管炎组织学特征的胆汁淤积性肝炎一例
DOI：
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发表时间：
2011
影响因子：
2.3
通讯作者：
H. Yokomori
中科院分区：
文献类型：
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作者：
Hajime Takeuchi;T. Kaneko;Toshikazu Otsuka;Kumiko Tahara;T. Motoori;M. Ohbu;M. Oda;H. Yokomori
本报告描述了一个病例显示组织学特征的急性胆管炎与非处方药。一名48岁的妇女被诊断为全身不适和进行性黄疸。对患者病史的全面审查显示，患者曾服用过一种非处方药Pabron Gold®，可能导致肝损伤。实验室检查显示黄疸和肝功能障碍。经内视镜逆行性胆管造影未发现肝外胆管扩张或结石。肝活检提示急性胆管炎累及中性粒细胞和嗜酸性粒细胞。电子显微镜显示破碎的细胞核，表明退行性胆管相关上皮细胞处于凋亡过程中。
This report describes a case showing histologic features of acute cholangitis with an over-the-counter drug. A 48-year-old woman was diagnosed with general malaise and progressive jaundice. A thorough review of her medical history revealed that the patient had taken an over-the-counter drug, Pabron Gold®, which she had used previously, that may have caused liver injury. Laboratory investigations revealed jaundice and liver dysfunction. Endoscopic retrograde cholangiography detected no extrahepatic biliary duct dilatation or stones. Liver biopsy indicated acute cholangitis involving neutrophils and eosinophils. Electron microscopy revealed fragmented nuclei, indicating that the degenerative bile duct-related epithelial cells were in an apoptotic process.
影响因子：
3.8
作者：
Jaeschke, H;Gores, GJ;Lemasters, JJ
通讯作者：
Lemasters, JJ