Modeling of Laser Coagulation of Tissue With MRI Temperature Monitoring
Modeling of Laser Coagulation of Tissue With MRI Temperature Monitoring
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DOI：
10.1115/1.4001395
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发表时间：
2010-06-01
影响因子：
1.7
通讯作者：
Saidel, Gerald M.
中科院分区：
文献类型：
--
作者：
Chen, Xin;Saidel, Gerald M.
来自激光源的光能通过具有最小侵入性的光纤探针被递送到身体组织中，已被用于消融实体肿瘤。这种热凝固过程可以通过连续磁共振成像（MRI）准确地引导和监测，因为激光能量输送系统不干扰MRI。本报告涉及组织激光凝固的数学建模和分析。该模型旨在对凝血过程中获得的磁共振图像进行“实时”分析，以指导临床治疗。建立了组织对激光热源的热响应数学模型。为了快速模拟，热模型的近似解被用来预测由激光能量线源引起的温度分布和组织损伤的动态。这些模拟的有效性进行了测试，通过比较与基于MRI的温度数据在兔体内实验。模型模拟的温度分布和预测的病变动力学与基于MRI的数据密切对应。这些结果证明了在激光加热组织期间使用快速建模和MRI技术的这种组合的潜力，用于在激光加热期间在线预测肿瘤病变尺寸。[DOI：10.1115/1.4001395]
Light energy from a laser source that is delivered into body tissue via a fiber-optic probe with minimal invasiveness has been used to ablate solid tumors. This thermal coagulation process can be guided and monitored accurately by continuous magnetic resonance imaging (MRI) since the laser energy delivery system does not interfere with MRI This report deals with mathematical modeling and analysis of laser coagulation of tissue. This model is intended for "real-time" analysis of magnetic resonance images obtained during the coagulation process to guide clinical treatment. A mathematical model is developed to simulate the thermal response of tissue to a laser light heating source. For fast simulation, an approximate solution of the thermal model is used to predict the dynamics of temperature distribution and tissue damage induced by a laser energy line source. The validity of these simulations is tested by comparison with MRI-based temperature data acquired from in vivo experiments in rabbits. The model-simulated temperature distribution and predicted lesion dynamics correspond closely with MRI-based data. These results demonstrate the potential for using this combination of fast modeling and MRI technologies during laser heating of tissue for online prediction of tumor lesion size during laser heating. [DOI: 10.1115/1.4001395]