Developmental delay in P300 production in children at high risk for developing alcohol-related disorders
Developmental delay in P300 production in children at high risk for developing alcohol-related disorders
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DOI：
10.1016/s0006-3223(99)00032-3
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发表时间：
1999-10-01
影响因子：
10.6
通讯作者：
Connolly, J
中科院分区：
文献类型：
--
作者：
Hill, SY;Shen, S;Connolly, J
背景：经常有报道称，处于酒精中毒高风险的儿童和青少年的 P300 波幅降低。据推测，这种降低代表 P300 波幅达到适龄水平的发育延迟。本研究通过对每年获得的纵向数据进行潜在生长分析，试图定义正常生长，并确定高风险儿童中观察到的模式是否与正常低风险对照中获得的模式不同。方法：使用临床评估 (K-SADS) 和同一天进行的 ERP 评估，对来自高风险或低风险家庭的总共 156 名儿童进行了多次评估（三分之二超过 4 次）。总共 635 项独立评估可用于建模。结果：二次生长曲线显示，高风险男性的 P300 振幅变化速度比低风险男性慢。仅当考虑到 K-SADS 诊断时，高危女孩才表现出视觉 P300 振幅降低。 P300 潜伏期没有差异。结论：这项研究证实了这样的假设：当处于酒精中毒高风险的男性中看到 P300 振幅降低时，这是由于发育迟缓。生物精神病学 1999；46：970-981 (C) 1999 生物精神病学协会。
Background: Reduction of P300 amplitude in children and adolescents at high risk for developing alcoholism has frequently been reported It has been hypothesized that this reduction represents a developmental delay in reaching age-appropriate levels in P300 amplitude. Using latent growth analysis of longitudinal data obtained at yearly intervals, this study seeks to define normal growth, and determine if the pattern seen in high-risk children differs from that obtained in normal low-risk controls.Methods: A total of 156 children from either high or low-risk families have been assessed multiple times (two-thirds more than 4 times) using both a clinical assessment (K-SADS) and ERP evaluation performed on the same day. A total of 635 separate assessments were available for modeling.Results: Quadratic growth curves revealed a slower rate of change in P300 amplitude in high-risk than low-risk males. High-risk girls showed reduced visual P300 amplitude only when the presence of a K-SADS diagnosis was considered. No differences were seen for P300 latency.Conclusions: This study confirms the hypothesis that when reduction of P300 amplitude is seen in males at high risk for developing alcoholism, it is due to a developmental delay. Biol Psychiatry 1999;46:970-981 (C) 1999 Society of Biological Psychiatry.