Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects.
Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects.
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长非编码 RNA 作为乳腺癌潜在诊断和预后生物标志物：进展与前景
DOI：
10.3389/fonc.2021.710538
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Lu C;Wei D;Zhang Y;Wang P;Zhang W
乳腺癌是全世界妇女中最常见的恶性肿瘤，不包括非黑色素瘤皮肤癌。现在已经很好地理解，乳腺癌是一种异质性实体，表现出独特的组织学和生物学特征，治疗反应和预后模式。因此，鉴定新的理想的诊断和预后生物标志物是至关重要的。长链非编码RNA（lncRNA）通常被定义为长度超过200个核苷酸且缺乏编码潜力的转录物。广泛的研究表明，lncRNA参与多种人类癌症，包括乳腺癌。表达异常的LncRNA可以作为癌基因或抑癌基因调节恶性转化过程，如增殖、侵袭、迁移和耐药性。有趣的是，lncRNA的表达谱往往具有高度的细胞类型特异性、组织特异性、疾病特异性或发育阶段特异性，这使得它们成为乳腺癌诊断和预后的合适生物标志物。
Breast cancer is the most common malignancy among women worldwide, excluding non-melanoma skin cancer. It is now well understood that breast cancer is a heterogeneous entity that exhibits distinctive histological and biological features, treatment responses and prognostic patterns. Therefore, the identification of novel ideal diagnostic and prognostic biomarkers is of utmost importance. Long non-coding RNAs (lncRNAs) are commonly defined as transcripts longer than 200 nucleotides that lack coding potential. Extensive research has shown that lncRNAs are involved in multiple human cancers, including breast cancer. LncRNAs with dysregulated expression can act as oncogenes or tumor-suppressor genes to regulate malignant transformation processes, such as proliferation, invasion, migration and drug resistance. Intriguingly, the expression profiles of lncRNAs tend to be highly cell-type-specific, tissue-specific, disease-specific or developmental stage-specific, which makes them suitable biomarkers for breast cancer diagnosis and prognosis.
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