Effects of prostaglandin E2, prostaglandin I2 and 6-keto-prostaglandin F1 alpha on adrenergic neurotransmission in the pulmonary artery of the rabbit.
Effects of prostaglandin E2, prostaglandin I2 and 6-keto-prostaglandin F1 alpha on adrenergic neurotransmission in the pulmonary artery of the rabbit.
复制标题
前列腺素 E2、前列腺素 I2 和 6-酮前列腺素 F1 α 对兔肺动脉肾上腺素能神经传递的影响。
DOI：
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发表时间：
1978
影响因子：
5
通讯作者：
K. Starke
中科院分区：
文献类型：
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作者：
R. Weitzell;A. Steppeler;K. Starke
将兔肺动脉条与 3H-去甲肾上腺素一起预孵育，然后以 2 或 4 Hz 进行灌注和电刺激。 PGE2和PGI2减少了刺激引起的总氚和3H-去甲肾上腺素的溢出。 PGI2 的效力比 PGE2 低约 10 倍。高浓度的 6-keto-PGF 1alpha 也减少了诱发的溢出，但效果很小。结论是，与E系列PG相比，PGI2是去甲肾上腺素释放相对较弱的抑制剂。
Strips of the rabbit pulmonary artery were preincubated with 3H-noradrenaline and then superfused and stimulated electrically at 2 or 4 Hz. PGE2 and PGI2 reduced the stimulation-evoked overflow of total tritium and 3H-noradrenaline. PGI2 was about 10 times less potent than PGE2. High concentrations of 6-keto-PGF 1alpha also diminished the evoked overflow, but the effect was small. It is concluded that PGI2, in comparison with PGs of the E series, is a relatively weak inhibitor of noradrenaline release.