Tumor suppressor function of miR-129-5p in lung cancer
Tumor suppressor function of miR-129-5p in lung cancer
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DOI：
10.3892/ol.2019.10241
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发表时间：
2019-06-01
期刊：
影响因子：
2.9
通讯作者：
Wang, Jiuhui
中科院分区：
文献类型：
--
作者：
Li, Ge;Xie, Jiahang;Wang, Jiuhui
肺癌在世界范围内造成严重的健康问题，在中国看来，它除了是城市居民死亡的主要原因外，还是农村人口死亡的第二大原因，排在肝细胞癌之前。80%到85%的肺癌被归类为非小细胞肺癌(NSCLC)。高迁移率族蛋白1(HMGB1)在肿瘤微环境和抗肿瘤反应中发挥重要作用，并可能被microRNA(MiR)靶向。在本研究中，miR-129-5p被确定为靶向HMGB1，miR-129-5p在非小细胞肺癌组织中表达水平较低。MiR-129-5p过表达抑制细胞增殖，促进细胞凋亡。综上所述，本研究结果提示了miR-129-5p的抑制作用，为进一步研究miR-129-5p提供了一个新的治疗靶点。
Lung cancer causes severe health problems worldwide and, in China, besides being the principal cause of mortality among urbanites, it is the second leading cause of mortality in the rural population, preceded by hepatocellular carcinoma. Between 80 and 85% of lung cancer is classified as non-small cell lung cancer (NSCLC). The high mobility group box 1 (HMGB1) protein serves an important function in the tumor microenvironment and antitumor response, and may be targeted by microRNA (miR). In the present study, miR-129-5p was identified to target HMGB1 and miR-129-5p exhibited low expression levels in NSCLC tissues. Overexpression of miR-129-5p inhibited cell proliferation and promoted cell apoptosis. In conclusion, the results of the present study suggested the inhibitory function of miR-129-5p and revealed a novel therapeutic target for further investigation.