総説 プリオン病研究の進歩-医原性プリオン感染について
総説 プリオン病研究の進歩-医原性プリオン感染について
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朊病毒病研究进展回顾——医源性朊病毒感染
DOI：
10.11477/mf.1416201542
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
小林 篤史
中科院分区：
文献类型：
--
作者：
M. Oe;K. Ojima;S. Muroya;小林 篤史
医源性Creutzfeldt-Jakob病（CJD）的病理学和生物化学特征是CJD患者的特征。根据病理学和生物化学特征，我们在一名神经外科医生和一名有神经外科病史的患者中发现了医源性CJD病例。此外，偶尔会注意到通过受污染的神经外科器械接触疑似克雅氏病的事件。因此，提高对CJD病例的识别和神经外科器械的跟踪是预防医源性CJD通过神经外科器械传播的必要措施。此外，越来越多的证据表明，某些错误折叠的蛋白质和淀粉样蛋白，以及朊病毒蛋白，是在个体之间传播。我们未来的任务是评估医源性传播的潜在风险，并为这些感染性蛋白制定预防策略。
Recent progress in understanding of iatrogenic Creutzfeldt-Jakob disease (CJD) has revealed pathological and biochemical features specific to patients with iatrogenic CJD Based on the pathological and biochemical characteristics, we have identified iatrogenic CJD cases among presumed sporadic cases; in a neurosurgeon and in a patient with a medical history of neurosurgery. In addition, incidents of suspected CJD exposure via contaminated neurosurgical instruments are occasionally noted. Therefore, improvement of CJD case recognition and tracking of neurosurgical instruments are necessary to prevent iatrogenic CJD transmission via neurosurgical instruments. Further, accumulating evidence suggests that certain misfolded proteins and amyloid proteins, as well as prion proteins, are transmissible between individuals. Evaluation of the potential risks of iatrogenic transmission and the development of preventative strategies for these infectious proteins are our future tasks.