Studies of Candida serology in denture stomatitis patients.
Studies of Candida serology in denture stomatitis patients.
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义齿性口炎患者念珠菌血清学研究。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
K. Holmberg
中科院分区：
文献类型：
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作者：
T. Bergendal;K. Holmberg
该研究的目的是通过血凝素和沉淀素试验来确定对念珠菌的体液抗体反应，并将这些结果与口腔和粪便中的酵母菌定植以及治疗后的复发趋势联系起来；进一步评价念珠菌血清学是否可以作为预测义齿口炎危险人群的工具。采用被动血凝（HA）和免疫电渗透（CIE）试验对51例义齿口炎患者进行血清学检测，并与对照组25例进行比较。血清中对白色念珠菌多糖（甘露聚糖）抗原的血凝素滴度（≥1:160）和对白色念珠菌粗质抗原的血凝素沉淀升高的患者明显多于对照组（P < 0.01）。在义齿口腔炎组中，血清中血凝和沉淀假丝酵母抗体的存在与口腔部位/粪便中酵母菌的定植、义齿基托上的酵母菌评分和腭红斑评分无相关性。局部口服抗真菌药物治疗后，血清念珠菌血凝素滴度和血清沉淀素无明显变化。血清学测试可能是有用的指导，在一组选定的病人继续修复治疗和作为预后工具。
The aim of the study was to determine the humoral antibody response to Candida by means of hemagglutinin and precipitin tests and to correlate these results to yeast colonization in the oral sites and feces and to the relapse tendency after treatment; and furthermore, to evaluate whether Candida serology can serve as a tool to predict a denture stomatitis risk group. The serologic tests were performed by means of passive hemagglutination (HA) and immunoelectroosmophoresis (counterimmunoelectrophoresis, CIE) tests in 51 denture stomatitis patients and compared with 25 individuals in the reference group. There were significantly more patients with increased hemagglutinin titers (pos. greater than or equal to 1:160) to Candida albicans polysaccharide (mannan) antigen and/or precipitin to crude C. albicans cytoplasmic antigen in serum (P less than 0.01) than in the reference group. In the denture stomatitis group there was no correlation between the presence of hemagglutinating and precipitating Candida antibody in serum and the parameters yeast colonization of the oral sites/feces, yeast score on the denture base and palatal erythema score. After local oral antimycotic treatment there was no significant change in the serum Candida hemagglutinin titers and serum precipitins. Serologic tests might be useful as a guidance in a selected group of patients for continued prosthetic treatment and as a prognostic instrument.