A COMPARATIVE STUDY OF THE METABOLIC EFFECTS OF TESTOSTERONE PROPIONATE IN NORMAL MEN AND WOMEN AND IN EUNUCHOIDISM1,2

A COMPARATIVE STUDY OF THE METABOLIC EFFECTS OF TESTOSTERONE PROPIONATE IN NORMAL MEN AND WOMEN AND IN EUNUCHOIDISM1,2
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丙酸睾酮在正常男性和女性以及阉割主义中代谢影响的比较研究1,2

DOI:
10.1210/endo-26-1-26
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发表时间:
1940
期刊:
影响因子:
4.8
通讯作者:
G. Lotwin
G. Lotwin
中科院分区:
医学2区
文献类型:
--
作者:
A. Kenyon;K. Knowlton;I. Sandiford;F. C. Koch;G. Lotwin

文献摘要

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LAST YEAR, in conjunction with A. H. Bryan, we described our experiences with the metabolic effects of daily injections of testosterone propionate in 4 eunuchoids, one of whom had pituitary damage from a suprasellar cyst (1,2). There appeared a uniform decline in urinary nitrogen reflected in the urea fraction and unaccompanied by increase in the plasma protein, non-protein nitrogen, urea or hemoglobin concentrations in the blood; a decline in urinary sodium associated, except in one instance, with a somewhat smaller decline in urinary chloride; a slight decline in urinary potassium in 2 experiments, of which one was fragmentary; a reduction in urine volume and a gain in weight due chiefly to water held with the retained electrolytes and nitrogen. Urinary creatinine remained unaffected while creatine declined in the 2 experiments in which spontaneous creatinuria was sufficiently intense and sustained to permit satisfactory study.