MAPPING OF MULTIPLE INTESTINAL NEOPLASIA (MIN) TO PROXIMAL CHROMOSOME-18 OF THE MOUSE
MAPPING OF MULTIPLE INTESTINAL NEOPLASIA (MIN) TO PROXIMAL CHROMOSOME-18 OF THE MOUSE
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DOI：
10.1006/geno.1993.1002
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发表时间：
1993-01-01
期刊：
影响因子：
4.4
通讯作者：
MOSER, AR
中科院分区：
文献类型：
--
作者：
LUONGO, C;GOULD, KA;MOSER, AR
通过分析限制性片段长度多态性和简单序列长度多态性在两个分离Minmutation的种内杂交后代中的遗传，已经定位了小鼠的Min（multipleaplerinalneoplasia）突变，Min是Apc的突变等位基因，Apc是人类APC（adenomatouspolyposisscoli）基因的小鼠同源物，定位于近端18号染色体。ApctMcc是人MCC（mutated incolorectalcancer）基因的小鼠同源物，尽管ApctMcc间隔中的基因顺序与APC到MCC间隔中的基因顺序不同，但ApctMcc之间的同线性在小鼠和人之间是保守的。
TheMin(multipleintestinalneoplasia) mutation of the mouse has been mapped by analyzing the inheritance of restriction fragment length polymorphisms and simple sequence length polymorphisms in progeny from two intraspecific crosses segregating for theMinmutation.Min, a mutant allele ofApc, the mouse homolog of the human APC (adenomatouspolyposiscoli) gene, maps to proximal chromosome 18. The synteny betweenApcandMcc, the mouse homolog of the human MCC (mutated incolorectalcancer) gene, is conserved between mouse and human, although the gene order in theApctoMccinterval is different from that in the APC to MCC interval.