Development and clinical application of the noninvasive thrombus detection method by NIR laser
Development and clinical application of the noninvasive thrombus detection method by NIR laser
复制标题
近红外激光无创血栓检测方法的开发及临床应用
DOI：
10.1109/iembs.2002.1053035
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Y. Sakakibara
中科院分区：
文献类型：
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作者：
H. Koguchi;Yoshiyuki Sankai;Kazuhiko Hanzawa;T. Jikuya;T. Tsutsui;Y. Sakakibara
在人工心脏的发展过程中，血栓的形成仍然是一个严重的问题。然而，目前还没有有效的方法来检测血栓。光学测量方法是实现血栓无创检测的最佳途径之一。本研究的目的是建立近红外激光无创血栓检测方法，并将其应用于临床。考虑到血栓和血液的光学特性，我们研制了新型血栓检测系统。利用该测量系统对人工心脏循环系统中塑料微珠(r=0.2 mm)和硅藻粉(0.1次/0.02 mm)等假血栓进行了模型实验和动物实验。实验结果证实了该方法的血栓检测性能和安全性。征得知情同意后，对临床应用的人工心脏(LVAS)患者进行测量检查，并检测到与动物实验相对应的相似信号(LMES；激光检测微栓子信号)。提出的近红外激光无创血栓检测方法可用于临床人工心脏血栓形成的监测。
In development of an artificial heart, thrombus formation is still serious problem. However, there is no effective means to detect a thrombus. An optical measurement method is one of the best approaches which realize noninvasive thrombus detection. The purpose of this research is to develop the noninvasive thrombus detection method using NIR (Near Infra-Red) laser, and to apply the method to clinical use. By considering the optical characteristic of a thrombus and blood, we have developed the new thrombus detection system. By using this measurement system, the mockup experiment and the animal experiment were performed to detect a fake thrombus such as plastic beads (r=0.2 mm) and celite powder (0.1/spl times/0.02 mm) in the artificial heart circulatory system. The thrombus detection performance and safety of this method have been confirmed as the result of these experiments. After obtaining informed consent, the measurement examination was performed to the artificial heart (LVAS: Left Ventricular Assist System) use patient as the clinical application, and similar signals (LMES; Laser-detected Micro-Embolus Signals) corresponding to the animal experiment were detected. The proposed noninvasive thrombus detection method using NIR laser would be regarded as effective in the surveillance of the thrombus formation at the time of clinical artificial heart use.