Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression
Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression
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DOI：
10.1192/bjp.186.3.197
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发表时间：
2005-03-01
影响因子：
10.5
通讯作者：
Parker, G
中科院分区：
文献类型：
--
作者：
Hickie, I;Naismith, S;Parker, G
背景：在重度抑郁症患者中，海马体体积减小的情况报道并不一致。
目的：评估海马体体积、记忆以及关键的临床、血管和遗传风险因素之间的相互关系。
方法：共有66名抑郁症患者和20名对照参与者接受了磁共振成像和临床评估。收集了抑郁症严重程度、精神运动迟缓、言语和视觉记忆以及血管和特定遗传风险因素的测量数据。
结果：在老年抑郁症患者、早发性和晚发性疾病患者以及忧郁型患者中，海马体体积减小。海马体体积减小与视觉和言语记忆表现的缺陷有关。
结论：尽管海马体体积减小在晚发性抑郁症中最为显著，但患有早发性疾病的老年人也表现出体积变化和记忆丧失。没有明确的血管或遗传风险因素可以解释这些发现。海马体体积变化可能解释了抑郁症如何成为痴呆的一个风险因素。
利益声明：由澳大利亚国家卫生与医学研究委员会项目资助（编号953208）支持。
Background Hippocampal volume reduction has been reported inconsistently in people with major depression.Aims To evaluate the interrelationships between hippocampal volumes, memory and key clinical, vascular and genetic risk factors.Method Totals of 66 people with depression and 20 control participants underwent magnetic resonance imaging and clinical assessment. Measures of depression severity psychomotor retardation, verbal and visual memory and vascular and specific genetic risk factors were collected.Results Reduced hippocampal volumes occurred in older people with depression, those with both early-onset and late-onset disorders and those with the melancholic subtype. Reduced hippocampal volumes were associated with deficits in visual and verbal memory performance.Conclusions Although reduced hippocampal volumes are most pronounced in late-onset depression, older people with early-onset disorders also display volume changes and memory loss. No clear vascular or genetic risk factors explain these findings. Hippocampal volume changes may explain how depression emerges as a risk factor to dementia.Declaration of interest Supported by National Health and Medical Research Council Program Grant No. 953208.