Bariatric Surgery and the Incidence of Psoriasis and Psoriatic Arthritis in the Swedish Obese Subjects Study
Bariatric Surgery and the Incidence of Psoriasis and Psoriatic Arthritis in the Swedish Obese Subjects Study
复制标题
DOI：
10.1002/oby.21955
复制
发表时间：
2017-12-01
期刊：
影响因子：
6.9
通讯作者：
Carlsson, Lena M. S.
中科院分区：
文献类型：
--
作者：
Maglio, Cristina;Peltonen, Markku;Carlsson, Lena M. S.
目的：本研究的目的是在瑞典肥胖受试者研究中评估减肥手术（垂直胃成形术、胃束带或胃绕道术）与常规护理相比对银屑病和银屑病关节炎 (PsA) 发生率的影响。方法：本报告包括来自 SOS 研究的 1,991 名接受减肥手术的受试者和 2,018 名肥胖对照者；基线时，他们均未患有牛皮癣或银屑病关节炎。通过瑞典国家患者登记册和调查问卷检索有关银屑病和银屑病关节炎诊断的信息。结果：在长达 26 年的随访期间，与常规护理相比，减肥手术与较低的银屑病发病率相关（事件数 5174；风险比 0.65；95% CI：0.47-0.89；P50.008）。吸烟和较长时间的肥胖与较高的牛皮癣风险独立相关。在降低患牛皮癣的风险方面，三种手术程序没有发现显着差异。减肥手术与银屑病发病率之间的关联不受基线混杂因素的影响。比较手术组和对照组时，没有发现发生银屑病关节炎的风险存在显着差异（事件数量546）。结论：这项研究表明，与常规护理相比，减肥手术与较低的发生银屑病的风险相关。
Objective: The aim of this study was to assess the effect of bariatric surgery (vertical gastroplasty, gastric banding, or gastric bypass) compared with usual care on the incidence of psoriasis and psoriatic arthritis (PsA) in the Swedish Obese Subjects study.Methods: This report includes 1,991 subjects who underwent bariatric surgery and 2,018 controls with obesity from the SOS study; none of them had psoriasis or PsA at baseline. Information about psoriasis and PsA diagnosis was retrieved through the Swedish National Patient Register and questionnaires.Results: During follow-up for up to 26 years, bariatric surgery was associated with a lower incidence of psoriasis compared with usual care (number of events5174; hazard ratio 0.65; 95% CI: 0.47-0.89; P50.008). Both smoking and a longer duration of obesity were independently associated with a higher risk for psoriasis. No significant difference was detected among the three surgical procedures in terms of lowering the risk of developing psoriasis. The association between bariatric surgery and psoriasis incidence was not influenced by baseline confounders. No significant difference in the risk of developing PsA (number of events546) was detected when comparing the surgery and the control groups.Conclusions: This study shows that bariatric surgery is associated with a lower risk of developing psoriasis compared with usual care.