Ultraconserved regions encoding ncRNAs are, altered in human leukemias and carcinomas
Ultraconserved regions encoding ncRNAs are, altered in human leukemias and carcinomas
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DOI：
10.1016/j.ccr.2007.07.027
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发表时间：
2007-09-01
期刊：
影响因子：
50.3
通讯作者：
Croce, Carlo M.
中科院分区：
文献类型：
--
作者：
Calin, George A.;Liu, Chang-Gong;Croce, Carlo M.
非编码RNA（NCRNA）转录本被认为与人类肿瘤发生有关。我们！报告说，大量的基因组超保守区域（UCR）编码了一组特定的NCRNA，其表达在人类癌症中发生了改变。全基因组的分析表明，UCR在人类白血病和癌中具有独特的特征。 UCR经常位于癌症中涉及的脆弱部位和基因组区域。我们确定了某些UCR，其表达可能会受到人类慢性淋巴细胞性白血病异常表达的microRNA调节，并且我们证明了对过表达UCR的抑制会诱导结肠癌细胞的凋亡。我们的发现表明，NCRNA和非编码基因之间的相互作用比以前想象的要大得多。
Noncoding RNA (ncRNA) transcripts are thought to be involved in human tumorigenesis. WE! report that a large fraction of genomic ultraconserved regions (UCRs) encode a particular set of ncRNAs whose expression is altered in human cancers. Genome-wide profiling revealed that UCRs have distinct signatures in human leukemias and carcinomas. UCRs are frequently located at fragile sites and genomic regions involved in cancers. We identified certain UCRs whose expression may be regulated by microRNAs abnormally expressed in human chronic lymphocytic leukemia, and we proved that the inhibition of an overexpressed UCR induces apoptosis in colon cancer cells. Our findings argue that ncRNAs and interaction between noncoding genes are involved in tumorigenesis to a greater extent than previously thought.