A Novel Resting Strategy for Improving Islet Engraftment in the Liver
A Novel Resting Strategy for Improving Islet Engraftment in the Liver
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DOI：
10.1097/01.tp.0000437557.50261.b9
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发表时间：
2014-02-15
期刊：
影响因子：
6.2
通讯作者：
Goto, Masafumi
中科院分区：
文献类型：
--
作者：
Jimbo, Takuya;Inagaki, Akiko;Goto, Masafumi
背景：一些研究表明，移植后胰岛素治疗有利于胰岛移植物的休息。然而，胰岛素输注本身不足以完全抑制餐后高血糖引起的繁重工作量。因此，本研究探讨是否短期禁食结合胰岛素治疗可以有效地防止移植物衰竭后intraportal胰岛transplantation.Methods的同系大鼠胰岛移植物的边缘剂量intraportally到对照组，胰岛素治疗，胰岛素+休息组的链脲佐菌素诱导的糖尿病大鼠。对照组自由进食，不给予胰岛素治疗，其他组持续给予最佳剂量的胰岛素治疗，以维持正常血糖。结果胰岛素组和胰岛素+休息组的治愈率均明显高于对照组（P
Background Several studies have revealed that posttransplant insulin treatment is beneficial to rest the islet grafts. However, insulin infusion per se is not enough to completely suppress the heavy workload arising caused by postprandial hyperglycemia. Therefore, the present study examined whether short-term fasting combined with insulin treatment could effectively prevent graft exhaustion after intraportal islet transplantation.Methods A marginal dose of syngeneic rat islet grafts were transplanted intraportally into the control, insulin-treated, and insulin+rest groups of streptozotocin-induced diabetic rats. The control group fed freely without insulin treatment, and the other groups were continuously treated with an optimal amount of insulin to maintain normoglycemia. In addition, the insulin+rest group fasted and received total parenteral nutrition during the 2 weeks after transplantation.Results The curative rate was significantly higher in both the insulin and insulin+rest groups than the control group (P