Endotoxin tolerance does not alter open field-induced fever in rats.
Endotoxin tolerance does not alter open field-induced fever in rats.
复制标题
内毒素耐受不会改变大鼠旷场引起的发热。
DOI：
10.1016/s0031-9384(97)00515-5
复制
发表时间：
1998
影响因子：
2.9
通讯作者：
Kluger,MJ
中科院分区：
文献类型：
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作者：
Soszynski,D;Kozak,W;Kluger,MJ
Soszynski，D.，W.Kozak和M.J.Kluger。内毒素耐受不能改变大鼠旷场发热。PhysIOL Behav 63(4)689-692,1998研究表明，暴露在开阔的野外会导致大鼠体温升高。在许多方面，这种体温上升与内毒素和其他炎性刺激引起的发烧相似。反复注射内毒素的大鼠对内毒素的发热作用产生耐受性。我们假设，反复内毒素预处理可以改善因暴露于心理压力而引起的发烧。为了验证这一假设，我们比较了内毒素耐受的大鼠和不耐受内毒素的大鼠在开阔场地引起的发热。我们发现内毒素耐受性对野外发烧没有影响。
Soszynski, D., W. Kozak and M. J. Kluger. Endotoxin tolerance does not alter open field-induced fever in rat. Physiol Behav 63(4) 689–692, 1998. Exposure to an open field has been shown to cause a rise in the body temperature of rats. In many respects, this rise in body temperature is similar to fevers caused by endotoxin and other inflammatory stimuli. Rats repeatedly injected with endotoxin develop tolerance to the fever-inducing action of endotoxin. We hypothesized that repeated pretreatment with endotoxin would modify the fever caused by exposure to psychological stress. To test this hypothesis, we compared open field-induced fevers in rats made endotoxin tolerant to those rats not endotoxin tolerant. We found that endotoxin tolerance had no effect on open field fevers.