Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy)
Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy)
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DOI：
10.1016/j.phymed.2009.10.014
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发表时间：
2010-06-01
期刊：
影响因子：
7.9
通讯作者：
Gomez-Leyva, J. F.
中科院分区：
文献类型：
--
作者：
Gurrola-Diaz, C. M.;Garcia-Lopez, P. M.;Gomez-Leyva, J. F.
胰岛素抵抗、肥胖、高血压和血脂异常与代谢综合征（MeSy）密切相关，代谢综合征（MeSy）被认为是其演变为冠心病和糖尿病之前的可逆临床阶段。目前，玫瑰茄水提取物（HSE）的抗高血压和降血脂特性已在临床试验和体内实验中得到证实。本研究的目的是根据国家胆固醇教育计划成人治疗小组III（NCEP-ATP III）标准，评估玫瑰茄提取物粉末（HSEP）和公认的预防性治疗（饮食）对有和无MeSy的个体血脂谱的影响。该方案是以析因随机设计进行的随访研究（T1 =预防性治疗包括饮食，T2 = HSEP，T3 = HSEP +预防性治疗（饮食）X MeSy，非MeSy个体）。每日总剂量为100 mg HSEP胶囊口服给药1个月。根据NCEP-ATP III建议选择预防性治疗（饮食），并单独调整。在治疗前和治疗后测定所有个体的血液中的总胆固醇、LDL-c、HDL-c、VLDL-c、甘油三酯、葡萄糖、尿素、肌酐、AST和ALT水平。用HSEP治疗的MeSy患者具有显著降低的葡萄糖和总胆固醇水平、增加的HDL-c水平和改善的TAG/HDL-c比率（胰岛素抵抗的标志物）（t检验p < 0.05）。此外，在用HSEP加饮食治疗的MeSy患者中观察到降低胆固醇的作用，并且在用HSER治疗的没有MeSy的个体中观察到降低胆固醇的作用。当比较治疗之间的绝对差异的平均值时，发现总胆固醇、HDL-c和TAG/HDL-c比率的显著差异（ANOVA p < 0.02）。因此，除了有充分证据证明的玫瑰茄的消肿作用外，我们建议在与MeSy相关的血脂异常患者中使用HSEP。(C)2009年Elsevier GmbH。All rights reserved.
Insulin resistance, obesity, hypertension, and dyslipidemia are strongly associated with metabolic syndrome (MeSy), which is considered to be a reversible clinical stage before its evolution to coronary heart disease and diabetes. Currently, the antihypertensive and hypolipidemic properties of aqueous Hibiscus sabdanffa extracts (HSE) have been demonstrated in clinical trials and in vivo experiments. The aim of the present study was to evaluate the effects of a Hibiscus sabdanffa extract powder (HSEP) and a recognized preventive treatment (diet) on the lipid profiles of individuals with and without MeSy according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. The protocol was a follow-up study carried out in a factorial, randomized design (T1 = preventive treatment comprises Diet, T2 = HSEP, T3 = HSEP + preventive treatment (Diet) X MeSy, non-MeSy individuals). A total daily dose of 100 mg HSEP was orally administered in capsules for one month. The preventive treatment (diet) was selected according to NCEP-ATP III recommendations and adjusted individually. Total cholesterol, LDL-c, HDL-c, VLDL-c, triglycerides, glucose, urea, creatinine, AST, and ALT levels in the blood were determined in all individuals pre- and post-treatment. The MeSy patients treated with HSEP had significantly reduced glucose and total cholesterol levels, increased HDL-c levels, and an improved TAG/HDL-c ratio, a marker of insulin resistance (t-test p < 0.05). Additionally, a triglyceride-lowering effect was observed in MeSy patients treated with HSEP plus diet, and in individuals without MeSy treated with HSER Significant differences in total cholesterol, HDL-c, and the TAG/HDL-c ratio were found when the means of absolute differences among treatments were compared (ANOVA p < 0.02). Therefore, in addition to the well documented hypotensive effects of Hibiscus sabdariffa, we suggest the use of HSEP in individuals with dyslipidemia associated with MeSy. (C) 2009 Elsevier GmbH. All rights reserved.