Immune senescence and biomarkers profile of Bambui aged population-based cohort
Immune senescence and biomarkers profile of Bambui aged population-based cohort
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DOI：
10.1016/j.exger.2017.12.006
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发表时间：
2018-03-01
影响因子：
3.9
通讯作者：
Teixeira-Carvalho, Andrea
中科院分区：
文献类型：
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作者：
Lima Torres, Karen Cecilia;de Rezende, Vitor Bortolo;Teixeira-Carvalho, Andrea
在免疫衰老过程中，许多促炎标志物如细胞因子和趋化因子增加。Franceschi及其同事称之为炎症的这一过程与慢性炎症以及许多老年性疾病（如阿尔茨海默病和动脉粥样硬化）的行为学和病理生理学有关。了解老年人免疫功能的变化，可以为改善老年人免疫功能和提高老年人生活质量提供一定的干预措施。然而，识别一组潜在的生物标志物来监测衰老过程是非常困难的。此外，大多数评估免疫生物标志物特征的证据都是基于老年高加索人的数据。据我们所知，以前没有拉丁美洲老年人口为基础的队列评价免疫学参数沿着老化过程。目前的工作评估了CXCL 8，CXCL 9，CXCL 10，CCL 2，CCL 5，IL-1，IL-6，IL-12，TNF和IL-10血清水平在1494老年人60至95岁的人口为基础的老龄化队列在巴西。我们的数据表明，参与者成为IL-6，CXCL 8和CXCL 9的高生产者的阳性预测概率增加。此外，结果在男性和女性之间没有差异，除了CXCL 10只在男性中增加。在调整后的模型中，许多潜在的混杂因素（包括非洲基因组血统）的结果没有差异。总之，这些发现增加了关于衰老的免疫学方面的新见解，该研究得到了一项基于人群的队列研究的支持，该研究提供了与炎症提议相印证的证据，并资助建立用于监测老年人群健康状况的生物标志物。
During immunosenescence many proinflammatory markers such as cytokines and chemokines are increased. This process called by Franceschi and colleagues as inflammaging is associated with chronic inflammation and the ethiology and pathophysiolgy of many ageing diseases as Alzheimer's and atherosclerosis. The knowledge of immune profile during ageing may provide some interventions that would improve the immune function in elderly and quality of life for old people. However, the identification of a group of potential biomarkers to monitor the ageing process is very difficult. In addition, most of the evidence evaluating immune biomarkers profile is based on data from older Caucasian adults. To our knowledge, no previous Latin American old population- based cohort has evaluated immunological parameters along the ageing process. The present work evaluated CXCL8, CXCL9, CXCL10, CCL2, CCL5, IL-1, IL-6, IL-12, TNF and IL-10 serum levels in 1494 older adults aged 60 to 95 from a population based ageing cohort in Brazil. Our data suggest that there is an increased positive predicted probability of participants to be a high producer of IL-6, CXCL8 and CXCL9. Moreover, results did not differ between men and women, except for CXCL10 that increased only in men. Results were not different in the adjusted model by many potential confounders, including African genomic ancestry. Together, these findings add novel insights about the immunologic aspects of ageing supported by a large population-based cohort study that provides evidences that corroborate with the inflammaging proposal and subsidize the establishment of biomarkers for monitoring the health status of aged population.