Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells.
Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells.
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DOI：
10.1042/bst20130263
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发表时间：
2014-02
影响因子：
3.9
通讯作者：
Garbett D
中科院分区：
文献类型：
--
作者：
Viswanatha R;Bretscher A;Garbett D
微绒毛位于上皮细胞的顶端表面。最近对微绒毛蛋白ezrin和EBP50 （ezrin/radixin/moesin-binding phosphoprotein of 50kda）的研究揭示了微绒毛组分的动力学和调控，以及动态ezrin磷酸化循环如何将微绒毛限制在顶端膜上。在目前的审查中，我们首先总结背景，使我们能够将这些进展放在上下文中。
Microvilli are found on the apical surface of epithelial cells. Recent studies on the microvillar proteins ezrin and EBP50 (ezrin/radixin/moesin-binding phosphoprotein of 50 kDa) have revealed both the dynamics and the regulation of microvillar components, and how a dynamic ezrin phosphocycle is necessary to confine microvilli to the apical membrane. In the present review, we first summarize the background to allow us to place these advances in context.